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TargetTubulin
LigandBDBM50014846
Substrate/Competitorn/a
Meas. Tech.ChEBML_211170
Ki 780±n/a nM
Citation Li QWoods KWClaiborne AGwaltney SLBarr KJLiu GGehrke LCredo RBHui YHLee JWarner RBKovar PNukkala MAZielinski NATahir SKFitzgerald MKim KHMarsh KFrost DNg SCRosenberg SSham HL Synthesis and biological evaluation of 2-indolyloxazolines as a new class of tubulin polymerization inhibitors. Discovery of A-289099 as an orally active antitumor agent. Bioorg Med Chem Lett 12:465-9 (2002) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Tubulin
Name:Tubulin
Synonyms:Tubulin beta chain
Type:PROTEIN
Mol. Mass.:49932.38
Organism:Bos taurus
Description:ChEMBL_211651
Residue:445
Sequence:
MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEATGNKYV
PRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV
RKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVV
EPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMM
AACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG
LKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATADEQGEFEEEEGEDEA
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  Blast E-value cutoff:
BDBM50014846
n/a
NameBDBM50014846
Synonyms:(S)-N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide | (S)-colchicine | 7alphaH-colchicine | CHEMBL107 | COLCHICINE | N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]acetamide | colchicina | colchicinum
TypeSmall organic molecule
Emp. Form.C22H25NO6
Mol. Mass.399.437
SMILESCOc1cc2CC[C@H](NC(C)=O)c3cc(=O)c(OC)ccc3-c2c(OC)c1OC |r|
Structure
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