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TargetTubulin
LigandBDBM50109342
Substrate/Competitorn/a
Meas. Tech.ChEBML_211170
Ki 3690±n/a nM
Citation Li QWoods KWClaiborne AGwaltney SLBarr KJLiu GGehrke LCredo RBHui YHLee JWarner RBKovar PNukkala MAZielinski NATahir SKFitzgerald MKim KHMarsh KFrost DNg SCRosenberg SSham HL Synthesis and biological evaluation of 2-indolyloxazolines as a new class of tubulin polymerization inhibitors. Discovery of A-289099 as an orally active antitumor agent. Bioorg Med Chem Lett 12:465-9 (2002) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Tubulin
Name:Tubulin
Synonyms:Tubulin beta chain
Type:PROTEIN
Mol. Mass.:49932.38
Organism:Bos taurus
Description:ChEMBL_211651
Residue:445
Sequence:
MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEATGNKYV
PRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV
RKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVV
EPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMM
AACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG
LKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATADEQGEFEEEEGEDEA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50109342
n/a
NameBDBM50109342
Synonyms:1-Methyl-5-[(R)-5-(3,4,5-trimethoxy-phenyl)-4,5-dihydro-oxazol-2-yl]-1H-indole | CHEMBL143680
TypeSmall organic molecule
Emp. Form.C21H22N2O4
Mol. Mass.366.4104
SMILESCOc1cc(cc(OC)c1OC)[C@@H]1CN=C(O1)c1ccc2n(C)ccc2c1 |c:15|
Structure
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