Reaction Details |
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Target | cAMP-specific 3',5'-cyclic phosphodiesterase 4B |
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Ligand | BDBM14775 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_222610 |
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IC50 | 0.200000±n/a nM |
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Citation | Andrés, JI; Alonso, JM; Díaz, A; Fernández, J; Iturrino, L; Martínez, P; Matesanz, E; Freyne, EJ; Deroose, F; Boeckx, G; Petit, D; Diels, G; Megens, A; Somers, M; Van Wauwe, J; Stoppie, P; Cools, M; De Clerck, F; Peeters, D; de Chaffoy, D Synthesis and biological evaluation of imidazol-2-one and 2-cyanoiminoimidazole derivatives: novel series of PDE4 inhibitors. Bioorg Med Chem Lett12:653-8 (2002) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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cAMP-specific 3',5'-cyclic phosphodiesterase 4B |
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Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4B |
Synonyms: | 3',5'-cyclic phosphodiesterase | DPDE4 | Isoform PDE4B1 | PDE32 | PDE4B | PDE4B1 | PDE4B_HUMAN | Phosphodiesterase 4B | Phosphodiesterase 4B (PDE4B) | Phosphodiesterase 4B (PDE4B1) | Phosphodiesterase Type 4 (PDE4B) |
Type: | Protein |
Mol. Mass.: | 83318.87 |
Organism: | Homo sapiens (Human) |
Description: | Q07343 |
Residue: | 736 |
Sequence: | MKKSRSVMTVMADDNVKDYFECSLSKSYSSSSNTLGIDLWRGRRCCSGNLQLPPLSQRQS
ERARTPEGDGISRPTTLPLTTLPSIAITTVSQECFDVENGPSPGRSPLDPQASSSAGLVL
HATFPGHSQRRESFLYRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRSVR
NNFTILTNLHGTSNKRSPAASQPPVSRVNPQEESYQKLAMETLEELDWCLDQLETIQTYR
SVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKK
KQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSH
NRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHV
LLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHL
AVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTS
SGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEI
SPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSP
SPPLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLG
ETDIDIATEDKSPVDT
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BDBM14775 |
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n/a |
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Name | BDBM14775 |
Synonyms: | 3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-methoxybenzamide | 3-cyclopentyloxy-N-(3,5-dichloropyridin-4-yl)-4-methoxy-benzamide | CHEMBL42126 | Cpodpmb | Piclamilast | RPR-73401 |
Type | Small organic molecule |
Emp. Form. | C18H18Cl2N2O3 |
Mol. Mass. | 381.253 |
SMILES | COc1ccc(cc1OC1CCCC1)C(=O)Nc1c(Cl)cncc1Cl |
Structure |
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