| Reaction Details |
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 | Report a problem with these data |
| Target | Endothelin-converting enzyme 1 |
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| Ligand | BDBM50112398 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_64349 |
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| IC50 | 3800±n/a nM |
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| Citation |  Yamazaki, K; Hasegawa, H; Umekawa, K; Ueki, Y; Ohashi, N; Kanaoka, M Design, synthesis and biological activity of novel non-peptidyl endothelin converting enzyme inhibitors, 1-phenyl-tetrazole-formazan analogues. Bioorg Med Chem Lett12:1275-8 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Endothelin-converting enzyme 1 |
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| Name: | Endothelin-converting enzyme 1 |
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| Synonyms: | ECE1_RAT | ENDOTHELIN | Ece1 | Endothelin-converting enzyme 1 | Endothelin-converting enzyme 1 (ECE) |
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| Type: | Protein |
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| Mol. Mass.: | 86126.89 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | P42893 |
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| Residue: | 762 |
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| Sequence: | MGSLRPPQGLGLQWSSFFLGKKGPGLTVSLPLLASSLQVNFRSPRSGQRCWAARTSVEKR
LVVLVTLLAAGLVACLAALGIQYRTRTPPVCLTEACVSVTSSILNSMDPTVDPCQDFFSY
ACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASASEAEKKAQVYYRACMNE
TRIEELRAKPLMELIEKLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNS
NSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEDSIRPQMQQIL
DFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNAIFYPVEINESEPIV
VYDKEYLRQVSTLINSTDKCLLNNYMMWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTC
LPRWKFCVSDTENNLGFALGPMFVKATFAEDSKNIASEIILEIKKAFEESLSTLKWMDED
TRRSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSLRVTADQ
LRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPNALNFGGIGVVVGHE
LTHAFDDQGREYDKDGNLRPWWKNSSVEAFKQQTECMVQQYNNYSVNGEPVNGRHTLGEN
IADNGGLKAAYRAYQNWVKKNGAEQILPTLGLTSNQLFFLGFAQVWCSVRTPESSHEGLI
TDPHSPSRFRVIGSLSNSKEFSEHFRCPLGSPMNPRHKCEVW
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| BDBM50112398 |
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| n/a |
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| Name | BDBM50112398 |
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| Synonyms: | 5-{(2Z)-2-[[(E)-(4-ethylphenyl)diazenyl](phenyl)methylene]hydrazino}-1-phenyl-1H-tetrazole | CHEMBL23324 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H20N8 |
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| Mol. Mass. | 396.4478 |
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| SMILES | CCc1ccc(NN=C(N=Nc2nnnn2-c2ccccc2)c2ccccc2)cc1 |w:9.8,7.6| |
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| Structure | 
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