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TargetProthrombin
LigandBDBM50131471
Substrate/Competitorn/a
Meas. Tech.ChEBML_208517
Ki 0.060000±n/a nM
Citation Nantermet, PGBarrow, JCNewton, CLPellicore, JMYoung, MLewis, SDLucas, BJKrueger, JAMcMasters, DRYan, YKuo, LCVacca, JPSelnick, HG Design and synthesis of potent and selective macrocyclic thrombin inhibitors. Bioorg Med Chem Lett13:2781-4 (2003) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Prothrombin
Name:Prothrombin
Synonyms:Activation peptide fragment 1 | Activation peptide fragment 2 | Coagulation factor II | F2 | Prothrombin precursor | THRB_HUMAN | Thrombin heavy chain | Thrombin light chain
Type:Protein
Mol. Mass.:70029.57
Organism:Homo sapiens (Human)
Description:P00734
Residue:622
Sequence:
MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLEREC
VEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHV
NITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQE
CSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASA
QAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETG
DGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYI
DGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTEN
DLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHP
VCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDST
RIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKY
GFYTHVFRLKKWIQKVIDQFGE
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50131471
n/a
NameBDBM50131471
Synonyms:(14Z,21S)-21-benzyl-8,26-dichloro-12,17-dioxa-1,4,19,22,24-pentaazatricyclo[21.3.1.0^{6,11}]heptacosa-6(11),7,9,14,23,25-hexaene-3,18,27-trione | CHEMBL94952
TypeSmall organic molecule
Emp. Form.C27H27Cl2N5O5
Mol. Mass.572.44
SMILESClc1ccc2OC\C=C/COC(=O)NC[C@H](Cc3ccccc3)Nc3ncc(Cl)n(CC(=O)NCc2c1)c3=O |c:7|
Structure
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