| Reaction Details |
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 | Report a problem with these data |
| Target | Peroxisome proliferator-activated receptor alpha |
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| Ligand | BDBM50132578 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_153546 (CHEMBL766087) |
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| Ki | 98±n/a nM |
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| Citation |  Adams, AD; Hu, Z; von Langen, D; Dadiz, A; Elbrecht, A; MacNaul, KL; Berger, JP; Zhou, G; Doebber, TW; Meurer, R; Forrest, MJ; Moller, DE; Jones, AB O-arylmandelic acids as highly selective human PPAR alpha/gamma agonists. Bioorg Med Chem Lett13:3185-90 (2003) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Peroxisome proliferator-activated receptor alpha |
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| Name: | Peroxisome proliferator-activated receptor alpha |
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| Synonyms: | NR1C1 | Nuclear receptor subfamily 1 group C member 1 | PPAR | PPAR alpha/gamma | PPAR-alpha | PPARA | PPARA_HUMAN | Peroxisome Proliferator-Activated Receptor alpha | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor alpha (PPAR alpha) |
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| Type: | Enzyme |
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| Mol. Mass.: | 52222.08 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q07869 |
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| Residue: | 468 |
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| Sequence: | MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSC
PGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACE
GCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSE
KAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFV
IHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANL
DLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFD
FAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDI
FLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
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| BDBM50132578 |
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| n/a |
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| Name | BDBM50132578 |
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| Synonyms: | CHEMBL109161 | Phenyl-(7-propyl-3-trifluoromethyl-benzo[d]isoxazol-6-yloxy)-acetic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C19H16F3NO4 |
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| Mol. Mass. | 379.3298 |
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| SMILES | CCCc1c(OC(C(O)=O)c2ccccc2)ccc2c(noc12)C(F)(F)F |
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| Structure | 
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