Ki Summary

Reaction Details

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Target

Beta-galactoside alpha-2,6-sialyltransferase 1

Ligand

BDBM50310540

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_216152 (CHEMBL817949)

64000±n/a nM

Citation

Whalen, LJ; McEvoy, KA; Halcomb, RL Synthesis and evaluation of phosphoramidate amino acid-based inhibitors of sialyltransferases. Bioorg Med Chem Lett13:301-4 (2002) [PubMed]

More Info.:

Get all data from this article, Assay Method

Beta-galactoside alpha-2,6-sialyltransferase 1

Name:

Beta-galactoside alpha-2,6-sialyltransferase 1

Synonyms:

CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase | SIAT1_RAT | Siat1 | St6gal1

Type:

PROTEIN

Mol. Mass.:

46743.36

Organism:

Rattus norvegicus

Description:

ChEMBL_216152

Residue:

403

Sequence:

MIHTNLKKKFSLFILVFLLFAVICVWKKGSDYEALTLQAKEFQMPKSQEKVAMGSASQVV
FSNSKQDPKEDIPILSYHRVTAKVKPQPSFQVWDKDSTYSKLNPRLLKIWRNYLNMNKYK
VSYKGPGPGVKFSVEALRCHLRDHVNVSMIEATDFPFNTTEWEGYLPKENFRTKVGPWQR
CAVVSSAGSLKNSQLGREIDNHDAVLRFNGAPTDNFQQDVGSKTTIRLMNSQLVTTEKRF
LKDSLYTEGILIVWDPSVYHADIPKWYQKPDYNFFETYKSYRRLNPSQPFYILKPQMPWE
LWDIIQEISADLIQPNPPSSGMLGIIIMMTLCDQVDIYEFLPSKRKTDVCYYHQKFFDSA
CTMGAYDPLLFEKNMVKHLNEGTDEDIYLFGKATLSGFRNIRC

BDBM50310540

n/a

Name

BDBM50310540

Synonyms:

((2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl)methyl dihydrogen phosphate | ((2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate | CHEMBL307679 | CYTIDINE-5'-MONOPHOSPHATE | Phosphoric acid mono-[5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl] ester | cytidine 5'-phosphate

Type

Small organic molecule

Emp. Form.

C9H14N3O8P

Mol. Mass.

323.1965

SMILES

Nc1ccn([C@@H]2O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]2O)c(=O)n1 |r|

Structure