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TargetThymidine phosphorylase
LigandBDBM50122770
Substrate/Competitorn/a
Meas. Tech.ChEMBL_208378 (CHEMBL813686)
Ki 2600±n/a nM
Citation McNally, VA; Gbaj, A; Douglas, KT; Stratford, IJ; Jaffar, M; Freeman, S; Bryce, RA Identification of a novel class of inhibitor of human and Escherichia coli thymidine phosphorylase by in silico screening. Bioorg Med Chem Lett13:3705-9 (2003) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Thymidine phosphorylase
Name:Thymidine phosphorylase
Synonyms:ECGF1 | Gliostatin | PD-ECGF | Platelet-derived endothelial cell growth factor | TP | TYMP | TYPH_HUMAN | TdRPase | Thymidine Phosphorylase (TP) | Thymidine phosphorylase
Type:Enzyme
Mol. Mass.:49948.87
Organism:Homo sapiens (Human)
Description:The recombinant human thymidine phosphorylase (V79TP) was expressed in V79 Chinese hamster cells (Sigma, T-9319).
Residue:482
Sequence:
MAALMTPGTGAPPAPGDFSGEGSQGLPDPSPEPKQLPELIRMKRDGGRLSEADIRGFVAA
VVNGSAQGAQIGAMLMAIRLRGMDLEETSVLTQALAQSGQQLEWPEAWRQQLVDKHSTGG
VGDKVSLVLAPALAACGCKVPMISGRGLGHTGGTLDKLESIPGFNVIQSPEQMQVLLDQA
GCCIVGQSEQLVPADGILYAARDVTATVDSLPLITASILSKKLVEGLSALVVDVKFGGAA
VFPNQEQARELAKTLVGVGASLGLRVAAALTAMDKPLGRCVGHALEVEEALLCMDGAGPP
DLRDLVTTLGGALLWLSGHAGTQAQGAARVAAALDDGSALGRFERMLAAQGVDPGLARAL
CSGSPAERRQLLPRAREQEELLAPADGTVELVRALPLALVLHELGAGRSRAGEPLRLGVG
AELLVDVGQRLRRGTPWLRVHRDGPALSGPQSRALQEALVLSDRAPFAAPSPFAELVLPP
QQ
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  Blast E-value cutoff:
BDBM50122770
n/a
NameBDBM50122770
Synonyms:6-Amino-5-bromo-1H-pyrimidine-2,4-dione | 6-Amino-5-bromo-1H-pyrimidine-2,4-dione(6A5BU) | 6-amino-5-bromo-1,2,3,4-tetrahydropyrimidine-2,4-dione | 6-amino-5-bromopyrimidine-2,4(1H,3H)-dione | 6-amino-5-bromouracil | CHEMBL64909
TypeSmall organic molecule
Emp. Form.C4H4BrN3O2
Mol. Mass.205.997
SMILESNc1[nH]c(=O)[nH]c(=O)c1Br
Structure
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