Reaction Details |
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Target | Thymidine phosphorylase |
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Ligand | BDBM50122770 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_208378 (CHEMBL813686) |
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Ki | 2600±n/a nM |
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Citation | McNally, VA; Gbaj, A; Douglas, KT; Stratford, IJ; Jaffar, M; Freeman, S; Bryce, RA Identification of a novel class of inhibitor of human and Escherichia coli thymidine phosphorylase by in silico screening. Bioorg Med Chem Lett13:3705-9 (2003) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Thymidine phosphorylase |
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Name: | Thymidine phosphorylase |
Synonyms: | ECGF1 | Gliostatin | PD-ECGF | Platelet-derived endothelial cell growth factor | TP | TYMP | TYPH_HUMAN | TdRPase | Thymidine Phosphorylase (TP) | Thymidine phosphorylase |
Type: | Enzyme |
Mol. Mass.: | 49948.87 |
Organism: | Homo sapiens (Human) |
Description: | The recombinant human thymidine phosphorylase (V79TP) was expressed in V79 Chinese hamster cells (Sigma, T-9319). |
Residue: | 482 |
Sequence: | MAALMTPGTGAPPAPGDFSGEGSQGLPDPSPEPKQLPELIRMKRDGGRLSEADIRGFVAA
VVNGSAQGAQIGAMLMAIRLRGMDLEETSVLTQALAQSGQQLEWPEAWRQQLVDKHSTGG
VGDKVSLVLAPALAACGCKVPMISGRGLGHTGGTLDKLESIPGFNVIQSPEQMQVLLDQA
GCCIVGQSEQLVPADGILYAARDVTATVDSLPLITASILSKKLVEGLSALVVDVKFGGAA
VFPNQEQARELAKTLVGVGASLGLRVAAALTAMDKPLGRCVGHALEVEEALLCMDGAGPP
DLRDLVTTLGGALLWLSGHAGTQAQGAARVAAALDDGSALGRFERMLAAQGVDPGLARAL
CSGSPAERRQLLPRAREQEELLAPADGTVELVRALPLALVLHELGAGRSRAGEPLRLGVG
AELLVDVGQRLRRGTPWLRVHRDGPALSGPQSRALQEALVLSDRAPFAAPSPFAELVLPP
QQ
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BDBM50122770 |
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n/a |
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Name | BDBM50122770 |
Synonyms: | 6-Amino-5-bromo-1H-pyrimidine-2,4-dione | 6-Amino-5-bromo-1H-pyrimidine-2,4-dione(6A5BU) | 6-amino-5-bromo-1,2,3,4-tetrahydropyrimidine-2,4-dione | 6-amino-5-bromopyrimidine-2,4(1H,3H)-dione | 6-amino-5-bromouracil | CHEMBL64909 |
Type | Small organic molecule |
Emp. Form. | C4H4BrN3O2 |
Mol. Mass. | 205.997 |
SMILES | Nc1[nH]c(=O)[nH]c(=O)c1Br |
Structure |
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