| Reaction Details |
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 | Report a problem with these data |
| Target | Thymidine phosphorylase |
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| Ligand | BDBM50134398 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_208382 (CHEMBL813749) |
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| Ki | 25000000±n/a nM |
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| Citation |  McNally, VA; Gbaj, A; Douglas, KT; Stratford, IJ; Jaffar, M; Freeman, S; Bryce, RA Identification of a novel class of inhibitor of human and Escherichia coli thymidine phosphorylase by in silico screening. Bioorg Med Chem Lett13:3705-9 (2003) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Thymidine phosphorylase |
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| Name: | Thymidine phosphorylase |
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| Synonyms: | ECGF1 | Gliostatin | PD-ECGF | Platelet-derived endothelial cell growth factor | TP | TYMP | TYPH_HUMAN | TdRPase | Thymidine Phosphorylase (TP) | Thymidine phosphorylase |
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| Type: | Enzyme |
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| Mol. Mass.: | 49948.87 |
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| Organism: | Homo sapiens (Human) |
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| Description: | The recombinant human thymidine phosphorylase (V79TP) was expressed in V79 Chinese hamster cells (Sigma, T-9319). |
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| Residue: | 482 |
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| Sequence: | MAALMTPGTGAPPAPGDFSGEGSQGLPDPSPEPKQLPELIRMKRDGGRLSEADIRGFVAA
VVNGSAQGAQIGAMLMAIRLRGMDLEETSVLTQALAQSGQQLEWPEAWRQQLVDKHSTGG
VGDKVSLVLAPALAACGCKVPMISGRGLGHTGGTLDKLESIPGFNVIQSPEQMQVLLDQA
GCCIVGQSEQLVPADGILYAARDVTATVDSLPLITASILSKKLVEGLSALVVDVKFGGAA
VFPNQEQARELAKTLVGVGASLGLRVAAALTAMDKPLGRCVGHALEVEEALLCMDGAGPP
DLRDLVTTLGGALLWLSGHAGTQAQGAARVAAALDDGSALGRFERMLAAQGVDPGLARAL
CSGSPAERRQLLPRAREQEELLAPADGTVELVRALPLALVLHELGAGRSRAGEPLRLGVG
AELLVDVGQRLRRGTPWLRVHRDGPALSGPQSRALQEALVLSDRAPFAAPSPFAELVLPP
QQ
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| BDBM50134398 |
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| n/a |
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| Name | BDBM50134398 |
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| Synonyms: | 1-methyl-2,5-dioxo-4-pentylimidazolidine-4-carbaldehyde semicarbazone | CHEMBL124225 |
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| Type | Small organic molecule |
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| Emp. Form. | C11H19N5O3 |
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| Mol. Mass. | 269.3003 |
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| SMILES | CCCCCC1(NC(=O)N(C)C1=O)C=NNC(N)=O |w:14.15| |
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| Structure | 
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