Reaction Details |
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Target | Thymidine phosphorylase |
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Ligand | BDBM50121753 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_208373 (CHEMBL813681) |
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IC50 | 20±n/a nM |
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Citation | McNally, VA; Gbaj, A; Douglas, KT; Stratford, IJ; Jaffar, M; Freeman, S; Bryce, RA Identification of a novel class of inhibitor of human and Escherichia coli thymidine phosphorylase by in silico screening. Bioorg Med Chem Lett13:3705-9 (2003) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Thymidine phosphorylase |
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Name: | Thymidine phosphorylase |
Synonyms: | ECGF1 | Gliostatin | PD-ECGF | Platelet-derived endothelial cell growth factor | TP | TYMP | TYPH_HUMAN | TdRPase | Thymidine Phosphorylase (TP) | Thymidine phosphorylase |
Type: | Enzyme |
Mol. Mass.: | 49948.87 |
Organism: | Homo sapiens (Human) |
Description: | The recombinant human thymidine phosphorylase (V79TP) was expressed in V79 Chinese hamster cells (Sigma, T-9319). |
Residue: | 482 |
Sequence: | MAALMTPGTGAPPAPGDFSGEGSQGLPDPSPEPKQLPELIRMKRDGGRLSEADIRGFVAA
VVNGSAQGAQIGAMLMAIRLRGMDLEETSVLTQALAQSGQQLEWPEAWRQQLVDKHSTGG
VGDKVSLVLAPALAACGCKVPMISGRGLGHTGGTLDKLESIPGFNVIQSPEQMQVLLDQA
GCCIVGQSEQLVPADGILYAARDVTATVDSLPLITASILSKKLVEGLSALVVDVKFGGAA
VFPNQEQARELAKTLVGVGASLGLRVAAALTAMDKPLGRCVGHALEVEEALLCMDGAGPP
DLRDLVTTLGGALLWLSGHAGTQAQGAARVAAALDDGSALGRFERMLAAQGVDPGLARAL
CSGSPAERRQLLPRAREQEELLAPADGTVELVRALPLALVLHELGAGRSRAGEPLRLGVG
AELLVDVGQRLRRGTPWLRVHRDGPALSGPQSRALQEALVLSDRAPFAAPSPFAELVLPP
QQ
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BDBM50121753 |
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n/a |
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Name | BDBM50121753 |
Synonyms: | 1-(5-Chloro-2,6-dioxo-1,2,3,6-tetrahydro-pyrimidin-4-ylmethyl)-pyrrolidin-2-ylidene-ammonium | 1-[(5-chloro-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)methyl]pyrrolidin-2-iminium |
Type | Small organic molecule |
Emp. Form. | C9H12ClN4O2 |
Mol. Mass. | 243.67 |
SMILES | NC1=[N+](Cc2[nH]c(=O)[nH]c(=O)c2Cl)CCC1 |c:1| |
Structure |
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