| Reaction Details |
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 | Report a problem with these data |
| Target | Peptidyl-prolyl cis-trans isomerase A |
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| Ligand | BDBM50136487 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_92658 |
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| IC50 | 166±n/a nM |
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| Citation |  Evers, M; Barrière, JC; Bashiardes, G; Bousseau, A; Carry, JC; Dereu, N; Filoche, B; Henin, Y; Sablé, S; Vuilhorgne, M; Mignani, S Synthesis of non-immunosuppressive cyclophilin-Binding cyclosporin A derivatives as potential anti-HIV-1 drugs. Bioorg Med Chem Lett13:4415-9 (2003) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Peptidyl-prolyl cis-trans isomerase A |
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| Name: | Peptidyl-prolyl cis-trans isomerase A |
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| Synonyms: | CYPA | CYPA PPIase | Cyclophilin A | Cyclosporin A-binding protein | PPIA | PPIA_HUMAN | PPIase A | Peptidyl-prolyl cis-trans isomerase A | Rotamase A |
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| Type: | Protein |
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| Mol. Mass.: | 18015.32 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P62937 |
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| Residue: | 165 |
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| Sequence: | MVNPTVFFDIAVDGEPLGRVSFELFADKVPKTAENFRALSTGEKGFGYKGSCFHRIIPGF
MCQGGDFTRHNGTGGKSIYGEKFEDENFILKHTGPGILSMANAGPNTNGSQFFICTAKTE
WLDGKHVVFGKVKEGMNIVEAMERFGSRNGKTSKKITIADCGQLE
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| BDBM50136487 |
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| n/a |
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| Name | BDBM50136487 |
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| Synonyms: | CHEMBL442519 | [(40-OH)MeLeu]4-Cyclosporin A |
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| Type | Small organic molecule |
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| Emp. Form. | C62H111N11O13 |
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| Mol. Mass. | 1218.6106 |
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| SMILES | CC[C@@H]1NC(=O)C([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)(C)O)N(C)C(=O)CN(C)C1=O)C(C)C |
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| Structure | 
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