Reaction Details |
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Target | Delta-type opioid receptor |
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Ligand | BDBM50136594 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_145607 |
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Ki | 1200±n/a nM |
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Citation | Le Bourdonnec, B; Belanger, S; Cassel, JA; Stabley, GJ; DeHaven, RN; Dolle, RE trans-3,4-dimethyl-4-(3-carboxamidophenyl)piperidines: a novel class of micro-selective opioid antagonists. Bioorg Med Chem Lett13:4459-62 (2003) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Delta-type opioid receptor |
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Name: | Delta-type opioid receptor |
Synonyms: | D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 40382.98 |
Organism: | Homo sapiens (Human) |
Description: | Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor. |
Residue: | 372 |
Sequence: | MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVC
AVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELL
CKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVG
VPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRL
RSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAAL
HLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTAC
TPSDGPGGGAAA
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BDBM50136594 |
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n/a |
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Name | BDBM50136594 |
Synonyms: | 3-((3R,4R)-3,4-Dimethyl-1-phenethyl-piperidin-4-yl)-N-methyl-benzamide | CHEMBL136421 |
Type | Small organic molecule |
Emp. Form. | C23H30N2O |
Mol. Mass. | 350.4971 |
SMILES | CNC(=O)c1cccc(c1)[C@]1(C)CCN(CCc2ccccc2)C[C@@H]1C |
Structure |
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