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TargetMu-type opioid receptor
LigandBDBM50045767
Substrate/Competitorn/a
Meas. Tech.ChEMBL_148068 (CHEMBL754686)
IC50 2±n/a nM
Citation Le Bourdonnec, B; Belanger, S; Cassel, JA; Stabley, GJ; DeHaven, RN; Dolle, RE trans-3,4-dimethyl-4-(3-carboxamidophenyl)piperidines: a novel class of micro-selective opioid antagonists. Bioorg Med Chem Lett13:4459-62 (2003) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Mu-type opioid receptor
Name:Mu-type opioid receptor
Synonyms:M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:44789.51
Organism:Homo sapiens (Human)
Description:P35372
Residue:400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCP
PTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALAT
STLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDF
RTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFI
FAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHI
YVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNI
EQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
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  Blast E-value cutoff:
BDBM50045767
n/a
NameBDBM50045767
Synonyms:(+)-N-phenethyl trans-3(R),4(R)-dimethyl-4-(3-hydroxyphenyl)piperidine | 3-((3R,4R)-3,4-Dimethyl-1-phenethyl-piperidin-4-yl)-phenol | 3-(3,4-Dimethyl-1-phenethyl-piperidin-4-yl)-phenol | 3-(trans-3,4-dimethyl-1-phenethylpiperidin-4-yl)phenol | CHEMBL319536 | N-phenethyltrans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine
TypeSmall organic molecule
Emp. Form.C21H27NO
Mol. Mass.309.4452
SMILESC[C@H]1CN(CCc2ccccc2)CC[C@@]1(C)c1cccc(O)c1
Structure
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