| Reaction Details |
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 | Report a problem with these data |
| Target | Steryl-sulfatase |
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| Ligand | BDBM50366886 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_203055 (CHEMBL811559) |
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| Ki | 57000±n/a nM |
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| Citation |  Lapierre, J; Ahmed, V; Chen, MJ; Ispahany, M; Guillemette, JG; Taylor, SD The difluoromethylene group as a replacement for the labile oxygen in steroid sulfates: a new approach to steroid sulfatase inhibitors. Bioorg Med Chem Lett14:151-5 (2003) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Steryl-sulfatase |
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| Name: | Steryl-sulfatase |
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| Synonyms: | ARSC1 | ASC | Arylsulfatase C | STS | STS_HUMAN | Steroid sulfatase | Steryl-sulfate sulfohydrolase |
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| Type: | Enzyme |
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| Mol. Mass.: | 65503.66 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P08842 |
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| Residue: | 583 |
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| Sequence: | MPLRKMKIPFLLLFFLWEAESHAASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLAS
GGVKLTQHLAASPLCTPSRAAFMTGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAK
LLKDQGYSTALIGKWHLGMSCHSKTDFCHHPLHHGFNYFYGISLTNLRDCKPGEGSVFTT
GFKRLVFLPLQIVGVTLLTLAALNCLGLLHVPLGVFFSLLFLAALILTLFLGFLHYFRPL
NCFMMRNYEIIQQPMSYDNLTQRLTVEAAQFIQRNTETPFLLVLSYLHVHTALFSSKDFA
GKSQHGVYGDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGS
NGIYKGGKANNWEGGIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRI
IDGRDLMPLLEGKSQRSDHEFLFHYCNAYLNAVRWHPQNSTSIWKAFFFTPNFNPVGSNG
CFATHVCFCFGSYVTHHDPPLLFDISKDPRERNPLTPASEPRFYEILKVMQEAADRHTQT
LPEVPDQFSWNNFLWKPWLQLCCPSTGLSCQCDREKQDKRLSR
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| BDBM50366886 |
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| n/a |
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| Name | BDBM50366886 |
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| Synonyms: | CHEMBL1628110 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H22F2O4S |
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| Mol. Mass. | 384.437 |
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| SMILES | C[C@]12CC[C@H]3[C@@H](CCc4cc(ccc34)C(F)(F)S(O)(=O)=O)[C@@H]1CCC2=O |r| |
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| Structure | 
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