| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Voltage-dependent calcium channel subunit alpha-2/delta-1 |
|---|
| Ligand | BDBM50145307 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_32525 |
|---|
| IC50 | 29±n/a nM |
|---|
| Citation |  Lebsack, AD; Gunzner, J; Wang, B; Pracitto, R; Schaffhauser, H; Santini, A; Aiyar, J; Bezverkov, R; Munoz, B; Liu, W; Venkatraman, S Identification and synthesis of [1,2,4]triazolo[3,4-a]phthalazine derivatives as high-affinity ligands to the alpha 2 delta-1 subunit of voltage gated calcium channel. Bioorg Med Chem Lett14:2463-7 (2004) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Voltage-dependent calcium channel subunit alpha-2/delta-1 |
|---|
| Name: | Voltage-dependent calcium channel subunit alpha-2/delta-1 |
|---|
| Synonyms: | CA2D1_HUMAN | CACNA2D1 | CACNL2A | CCHL2A | MHS3 | Voltage-dependent calcium channel subunit alpha-2-1 | Voltage-dependent calcium channel subunit delta-1 | Voltage-gated calcium channel | Voltage-gated calcium channel alpha2/delta subunit 1 | Voltage-gated calcium channel subunit alpha-2/delta-1 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 124544.88 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P54289 |
|---|
| Residue: | 1103 |
|---|
| Sequence: | MAAGCLLALTLTLFQSLLIGPSSEEPFPSAVTIKSWVDKMQEDLVTLAKTASGVNQLVDI
YEKYQDLYTVEPNNARQLVEIAARDIEKLLSNRSKALVRLALEAEKVQAAHQWREDFASN
EVVYYNAKDDLDPEKNDSEPGSQRIKPVFIEDANFGRQISYQHAAVHIPTDIYEGSTIVL
NELNWTSALDEVFKKNREEDPSLLWQVFGSATGLARYYPASPWVDNSRTPNKIDLYDVRR
RPWYIQGAASPKDMLILVDVSGSVSGLTLKLIRTSVSEMLETLSDDDFVNVASFNSNAQD
VSCFQHLVQANVRNKKVLKDAVNNITAKGITDYKKGFSFAFEQLLNYNVSRANCNKIIML
FTDGGEERAQEIFNKYNKDKKVRVFTFSVGQHNYDRGPIQWMACENKGYYYEIPSIGAIR
INTQEYLDVLGRPMVLAGDKAKQVQWTNVYLDALELGLVITGTLPVFNITGQFENKTNLK
NQLILGVMGVDVSLEDIKRLTPRFTLCPNGYYFAIDPNGYVLLHPNLQPKPIGVGIPTIN
LRKRRPNIQNPKSQEPVTLDFLDAELENDIKVEIRNKMIDGESGEKTFRTLVKSQDERYI
DKGNRTYTWTPVNGTDYSLALVLPTYSFYYIKAKLEETITQARYSETLKPDNFEESGYTF
IAPRDYCNDLKISDNNTEFLLNFNEFIDRKTPNNPSCNADLINRVLLDAGFTNELVQNYW
SKQKNIKGVKARFVVTDGGITRVYPKEAGENWQENPETYEDSFYKRSLDNDNYVFTAPYF
NKSGPGAYESGIMVSKAVEIYIQGKLLKPAVVGIKIDVNSWIENFTKTSIRDPCAGPVCD
CKRNSDVMDCVILDDGGFLLMANHDDYTNQIGRFFGEIDPSLMRHLVNISVYAFNKSYDY
QSVCEPGAAPKQGAGHRSAYVPSVADILQIGWWATAAAWSILQQFLLSLTFPRLLEAVEM
EDDDFTASLSKQSCITEQTQYFFDNDSKSFSGVLDCGNCSRIFHGEKLMNTNLIFIMVES
KGTCPCDTRLLIQAEQTSDGPNPCDMVKQPRYRKGPDVCFDNNVLEDYTDCGGVSGLNPS
LWYIIGIQFLLLWLVSGSTHRLL
|
|
|
|---|
| BDBM50145307 |
|---|
| n/a |
|---|
| Name | BDBM50145307 |
|---|
| Synonyms: | (2-m-Tolyl-ethyl)-{1-[6-(3-trifluoromethyl-[1,2,4]triazolo[3,4-a]phthalazin-6-yloxymethyl)-pyridin-2-yl]-ethyl}-amine | CHEMBL430820 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C27H25F3N6O |
|---|
| Mol. Mass. | 506.5222 |
|---|
| SMILES | CC(NCCc1cccc(C)c1)c1cccc(COc2nn3c(nnc3c3ccccc23)C(F)(F)F)n1 |
|---|
| Structure | 
|
|---|
Search and Browse
