Reaction Details |
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Target | Sodium-dependent serotonin transporter |
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Ligand | BDBM50145343 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_201998 |
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Ki | 0.290000±n/a nM |
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Citation | Timms, GH; Boot, JR; Broadmore, RJ; Carney, SL; Cooper, J; Findlay, JD; Gilmore, J; Mitchell, S; Moore, NA; Pullar, I; Sanger, GJ; Tomlinson, R; Tree, BB; Wedley, S SAR development of a selective 5-HT1D antagonist/serotonin reuptake inhibitor lead using rapid parallel synthesis. Bioorg Med Chem Lett14:2469-72 (2004) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sodium-dependent serotonin transporter |
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Name: | Sodium-dependent serotonin transporter |
Synonyms: | 5-HT Transporter | 5-HTT | 5HT transporter | 5HTT | Anandamid membrane transporter, AMT | Anandamide membrane transporter, AMT | Monoamine transporters; Norepinephrine & serotonin | SC6A4_RAT | Slc6a4 | Sodium-dependent serotonin transporter | Sodium-dependent serotonin transporter (SERT) | imipramine receptor |
Type: | Multi-pass membrane protein |
Mol. Mass.: | 70168.43 |
Organism: | Rattus norvegicus (rat) |
Description: | P31652 |
Residue: | 630 |
Sequence: | METTPLNSQKVLSECKDREDCQENGVLQKGVPTTADRAEPSQISNGYSAVPSTSAGDEAS
HSIPAATTTLVAEIRQGERETWGKKMDFLLSVIGYAVDLGNIWRFPYICYQNGGGAFLLP
YTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTII
AWALYYLISSLTDRLPWTSCTNSWNTGNCTNYFAQDNITWTLHSTSPAEEFYLRHVLQIH
QSKGLQDLGTISWQLTLCIVLIFTVIYFSIWKGVKTSGKVVWVTATFPYIVLSVLLVRGA
TLPGAWRGVVFYLKPNWQKLLETGVWVDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQD
ALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPAS
TFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHIWAKRREWFVLIVVITCVLGSLLT
LTSGGAYVVTLLEEYATGPAVLTVALIEAVAVSWFYGITQFCSDVKEMLGFSPGWFWRIC
WVAISPLFLLFIICSFLMSPPQLRLFQYNYPHWSIVLGYCIGMSSVICIPTYIIYRLIST
PGTLKERIIKSITPETPTEIPCGDIRMNAV
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BDBM50145343 |
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n/a |
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Name | BDBM50145343 |
Synonyms: | 1-{2-[4-(6-Fluoro-benzofuran-3-yl)-3,6-dihydro-2H-pyridin-1-yl]-ethyl}-isochroman-6-carboxylic acid amide | CHEMBL82488 |
Type | Small organic molecule |
Emp. Form. | C25H25FN2O3 |
Mol. Mass. | 420.476 |
SMILES | NC(=O)c1ccc2C(CCN3CCC(=CC3)c3coc4cc(F)ccc34)OCCc2c1 |c:13| |
Structure |
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