Reaction Details |
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Target | Plasmepsin II |
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Ligand | BDBM50146530 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_154916 |
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IC50 | 123±n/a nM |
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Citation | Romeo, S; Dell'Agli, M; Parapini, S; Rizzi, L; Galli, G; Mondani, M; Sparatore, A; Taramelli, D; Bosisio, E Plasmepsin II inhibition and antiplasmodial activity of Primaquine-Statine 'double-drugs'. Bioorg Med Chem Lett14:2931-4 (2004) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Plasmepsin II |
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Name: | Plasmepsin II |
Synonyms: | Aspartic hemoglobinase II | PFAPD | PLM2_PLAFX | PMII | Plasmepsin 2 | Plasmepsin 2 (PM-II) | Plasmepsin-II |
Type: | Enzyme |
Mol. Mass.: | 51482.09 |
Organism: | Plasmodium falciparum |
Description: | P46925 |
Residue: | 453 |
Sequence: | MDITVREHDFKHGFIKSNSTFDGLNIDNSKNKKKIQKGFQILYVLLFCSVMCGLFYYVYE
NVWLQRDNEMNEILKNSEHLTIGFKVENAHDRILKTIKTHKLKNYIKESVNFLNSGLTKT
NYLGSSNDNIELVDFQNIMFYGDAEVGDNQQPFTFILDTGSANLWVPSVKCTTAGCLTKH
LYDSSKSRTYEKDGTKVEMNYVSGTVSGFFSKDLVTVGNLSLPYKFIEVIDTNGFEPTYT
ASTFDGILGLGWKDLSIGSVDPIVVELKNQNKIENALFTFYLPVHDKHTGFLTIGGIEER
FYEGPLTYEKLNHDLYWQITLDAHVGNIMLEKANCIVDSGTSAITVPTDFLNKMLQNLDV
IKVPFLPFYVTLCNNSKLPTFEFTSENGKYTLEPEYYLQHIEDVGPGLCMLNIIGLDFPV
PTFILGDPFMRKYFTVFDYDNHSVGIALAKKNL
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BDBM50146530 |
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n/a |
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Name | BDBM50146530 |
Synonyms: | (S)-2-[4-(4-{(S)-1-[(S)-1-((S)-2-Butylcarbamoyl-1-hydroxy-ethyl)-3-methyl-butylcarbamoyl]-2-methyl-butylcarbamoyl}-phenoxy)-benzoylamino]-4-methyl-pentanoic acid | CHEMBL98043 |
Type | Small organic molecule |
Emp. Form. | C38H56N4O8 |
Mol. Mass. | 696.8732 |
SMILES | CCCCNC(=O)C[C@H](O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)c1ccc(Oc2ccc(cc2)C(=O)N[C@@H](CC(C)C)C(O)=O)cc1)C(C)CC |
Structure |
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