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TargetHistone deacetylase 1/2/3/4/5/6/7/8/9/11/Polyamine deacetylase HDAC10
LigandBDBM50366962
Substrate/Competitorn/a
Meas. Tech.ChEMBL_87707 (CHEMBL877727)
IC50 84±n/a nM
Citation Nishino, N; Yoshikawa, D; Watanabe, LA; Kato, T; Jose, B; Komatsu, Y; Sumida, Y; Yoshida, M Synthesis and histone deacetylase inhibitory activity of cyclic tetrapeptides containing a retrohydroxamate as zinc ligand. Bioorg Med Chem Lett14:2427-31 (2004) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Histone deacetylase 1/2/3/4/5/6/7/8/9/11/Polyamine deacetylase HDAC10
Name:Histone deacetylase 1/2/3/4/5/6/7/8/9/11/Polyamine deacetylase HDAC10
Synonyms:Histone deacetylase
Type:n/a
Mol. Mass.:n/a
Description:ASSAY_ID of ChEMBL is 87707
Components:This complex has 11 components.
Component 1
Name:Histone deacetylase 2
Synonyms:3.5.1.98 | HD2 | HDAC2_MOUSE | Hdac2 | Histone deacetylase 2 | YY1 transcription factor-binding protein | Yy1bp
Type:PROTEIN
Mol. Mass.:55294.47
Organism:Mus musculus
Description:ChEMBL_117015
Residue:488
Sequence:
MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKA
TAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVA
GAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHH
GDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQ
IFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVAKTFNLPLLMLG
GGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYM
EKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEE
FSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDPKGA
KSEQLSNP
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Component 2
Name:Histone deacetylase 1
Synonyms:HD1 | HDAC1_MOUSE | Hdac1 | Histone deacetylase 1/2
Type:Protein
Mol. Mass.:55062.26
Organism:Mus musculus (Mouse)
Description:O09106
Residue:482
Sequence:
MAQTQGTKRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEEDPDKRISICSSDKRIACEEEF
SDSDEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
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Component 3
Name:Histone deacetylase 6
Synonyms:HD6 | HDAC6_MOUSE | Hdac6 | Histone Deacetylase 6 (HDAC6) | Histone deacetylase | Histone deacetylase mHDA2
Type:PROTEIN
Mol. Mass.:125762.28
Organism:Mus musculus
Description:ChEMBL_1460074
Residue:1149
Sequence:
MTSTGQDSSTRQRKSRHNPQSPLQESSATLKRGGKKCAVPHSSPNLAEVKKKGKMKKLSQ
PAEEDLVVGLQGLDLNPETRVPVGTGLVFDEQLNDFHCLWDDSFPESPERLHAIREQLIL
EGLLGRCVSFQARFAEKEELMLVHSLEYIDLMETTQYMNEGELRVLAETYDSVYLHPNSY
SCACLATGSVLRLVDALMGAEIRNGMAVIRPPGHHAQHNLMDGYCMFNHLAVAARYAQKK
HRIQRVLIVDWDVHHGQGTQFIFDQDPSVLYFSIHRYEHGRFWPHLKASNWSTIGFGQGQ
GYTINVPWNQTGMRDADYIAAFLHILLPVASEFQPQLVLVAAGFDALHGDPKGEMAATPA
GFAHLTHLLMGLAGGKLILSLEGGYNLRALAKGVSASLHTLLGDPCPMLESCVVPCASAQ
TSIYCTLEALEPFWEVLERSVETQEEDEVEEAVLEEEEEEGGWEATALPMDTWPLLQNRT
GLVYDEKMMSHCNLWDNHHPETPQRILRIMCHLEEVGLAARCLILPARPALDSELLTCHS
AEYVEHLRTTEKMKTRDLHREGANFDSIYICPSTFACAKLATGAACRLVEAVLSGEVLNG
IAVVRPPGHHAEPNAACGFCFFNSVAVAARHAQIIAGRALRILIVDWDVHHGNGTQHIFE
DDPSVLYVSLHRYDRGTFFPMGDEGASSQVGRDAGIGFTVNVPWNGPRMGDADYLAAWHR
LVLPIAYEFNPELVLISAGFDAAQGDPLGGCQVTPEGYAHLTHLLMGLAGGRIILILEGG
YNLASISESMAACTHSLLGDPPPQLTLLRPPQSGALVSISEVIQVHRKYWRSLRLMKMED
KEECSSSRLVIKKLPPTASPVSAKEMTTPKGKVPEESVRKTIAALPGKESTLGQAKSKMA
KAVLAQGQSSEQAAKGTTLDLATSKETVGGATTDLWASAAAPENFPNQTTSVEALGETEP
TPPASHTNKQTTGASPLQGVTAQQSLQLGVLSTLELSREAEEAHDSEEGLLGEAAGGQDM
NSLMLTQGFGDFNTQDVFYAVTPLSWCPHLMAVCPIPAAGLDVSQPCKTCGTVQENWVCL
TCYQVYCSRYVNAHMVCHHEASEHPLVLSCVDLSTWCYVCQAYVHHEDLQDVKNAAHQNK
FGEDMPHSH
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Component 4
Name:Histone deacetylase 5
Synonyms:HD5 | HDAC5_MOUSE | Hdac5 | Histone deacetylase | Histone deacetylase mHDA1
Type:PROTEIN
Mol. Mass.:120932.97
Organism:Mus musculus
Description:ChEMBL_87889
Residue:1113
Sequence:
MNSPNESDGMSGREPSLGILPRTPLHSIPVAVEVKPVLPGAMPSSMGGGGGGSPSPVELR
GALAGPMDPALREQQLQQELLVLKQQQQLQKQLLFAEFQKQHDHLTRQHEVQLQKHLKQQ
QEMLAAKRQQELEQQRQREQQRQEELEKQRLEQQLLILRNKEKSKESAIASTEVKLRLQE
FLLSKSKEPTPGGLNHSLPQHPKCWGAHHASLDQSSPPQSGPPGTPPSYKLPLLGPYDSR
DDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGTVISTFKKRAVEITGTGPGVSS
VCNSAPGSGPSSPNSSHSTIAENGFTGSVPNIPTEMIPQHRALPLDSSPNQFSLYTSPSL
PNISLGLQATVTVTNSHLTASPKLSTQQEAERQALQSLRQGGTLTGKFMSTSSIPGCLLG
VALEGDTSPHGHASLLQHVCSWTGRQQSTLIAVPLHGQSPLVTGERVATSMRTVGKLPRH
RPLSRTQSSPLPQSPQALQQLVMQQQHQQFLEKQKQQQMQLGKILTKTGELSRQPTTHPE
ETEEELTEQQEALLGEGALTIPREGSTESESTQEDLEEEEEEEEEEEEDCIQVKDEDGES
GPDEGPDLEESSAGYKKLFADAQQLQPLQVYQAPLSLATVPHQALGRTQSSPAAPGSMKS
PTDQPTVVKHLFTTGVVYDTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQETGLLGKCER
IRGRKATLDEIQTVHSEYHTLLYGTSPLNRQKLDSKKLLGPISQKMYAMLPCGGIGVDSD
TVWNEMHSSSAVRMAVGCLVELAFKVAAGELKNGFAIIRPPGHHAEESTAMGFCFFNSVA
ITAKLLQQKLSVGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNFFPGSGAPEE
VGGGPGVGYNVNVAWTGGVDPPIGDVEYLTAFRTVVMPIAQEFSPDVVLVSAGFDAVEGH
LSPLGGYSVTARCFGHLTRQLMTLAGGRVVLALEGGHDLTAICDASEACVSALLSVELQP
LDEAVLQQKPSVNAVATLEKVIEIQSKHWSCVQRFAAGLGCSLREAQTGEKEEAETVSAM
ALLSVGAEQAQAVATQEHSPRPAEEPMEQEPAL
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Component 5
Name:Histone deacetylase 4
Synonyms:3.5.1.98 | HD4 | HDAC4_MOUSE | Hdac4 | Histone deacetylase 4
Type:PROTEIN
Mol. Mass.:118571.33
Organism:Mus musculus
Description:ChEMBL_116900
Residue:1076
Sequence:
MSSQSHPDGLSGRDQPVELLNPARVNHMPSTVDVATALPLQVAPTAVPMDLRLDHQFSLP
LEPALREQQLQQELLALKQKQQIQRQILIAEFQRQHEQLSRQHEAQLHEHIKQQQEMLAM
KHQQELLEHQRKLERHRQEQELEKQHREQKLQQLKNKEKGKESAVASTEVKMKLQEFVLN
KKKALAHRNLNHCISSDPRYWYGKTQHSSLDQSSPPQSGVSASYNHPVLGMYDAKDDFPL
RKTASEPNLKLRSRLKQKVAERRSSPLLRRKDGPVATALKKRPLDVTDSACSSAPGSGPS
SPNSSSGNVSTENGIAPTVPSAPAETSLAHRLVTREGSVAPLPLYTSPSLPNITLGLPAT
GPAAGAAGQQDAERLALPALQQRILFPGTHLTPYLSTSPLERDGAAAHNPLLQHMVLLEQ
PPTQTPLVTGLGALPLHSQSLVGADRVSPSIHKLRQHRPLGRTQSAPLPQNAQALQHLVI
QQQHQQFLEKHKQQFQQQQLHLSKIISKPSEPPRQPESHPEETEEELREHQALLDEPYLD
RLPGQKEPSLAGVQVKQEPIESEEEEAEATRETEPGQRPATEQELLFRQQALLLEQQRIH
QLRNYQASMEAAGIPVSFGSHRPLSRAQSSPASATFPMSVQEPPTKPRFTTGLVYDTLML
KHQCTCGNTNSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHTLLY
GTNPLNRQKLDSSLTSVFVRLPCGGVGVDSDTIWNEVHSSGAARLAVGCVVELVFKVATG
ELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLNVSKILIVDWDVHHGNGTQ
QAFYNDPNVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLEPPMGDAEYL
AAFRTVVMPIANEFAPDVVLVSSGFDAVEGHPTPLGGYNLSAKCFGYLTKQLMGLAGGRL
VLALEGGHDLTAICDASEACVSALLGNELEPLPEKVLHQRPNANAVHSMEKVMDIHSKYW
RCLQRLSSTVGHSLIEAQKCEKEEAETVTAMASLSVGVKPAEKRSEEEPMEEEPPL
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Component 6
Name:Histone deacetylase 9
Synonyms:3.5.1.98 | HD7b | HD9 | HDAC9_MOUSE | Hdac7b | Hdac9 | Hdrp | Histone deacetylase 7B | Histone deacetylase 9 | Histone deacetylase-related protein | MEF2-interacting transcription repressor MITR | Mitr
Type:PROTEIN
Mol. Mass.:65701.37
Organism:Mus musculus
Description:ChEMBL_116900
Residue:588
Sequence:
MHSMISSVDVKSEVPMGLEPISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQ
KQLLIAEFQKQHENLTRQHQAQLQEHIKELLAIKQQQELLEKEQKLEQQRQEQEVERHRR
EQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTPTNGKNHSVGRHPKLWYTAA
HHTSLDQSSPPLSGTSPSYKYTLPGAQDSKDDFPLRKTASEPNLKVRSRLKQKVAERRSS
PLLRRKDGNLVTSFKKRVFEVAESSVSSSSPGSGPSSPNNGPAGNVTENEASALPPTPHP
EQLVPQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVPSPLNASNSLKDKQKCETQMLRQ
GVPLPSQYGSSIAASSSHVHVAMEGKPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHPQ
SPLATKERISPGIRGTHKLPRHRPLNRTQSAPLPQSTLAQLVIQQQHQQFLEKQKQYQQQ
IHMNKLLSKSIEQLKQPGSHLEEAEEELQGDQSMEDRAASKDNSARSDSSACVEDTLGQV
GAVKVKEEPVDSDEDAQIQEMECGEQAAFMQQVIGKDLAPGFVIKVII
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Component 7
Name:Histone deacetylase 7
Synonyms:3.5.1.98 | HD7 | HD7a | HDAC7_MOUSE | Hdac7 | Hdac7a | Histone deacetylase 7 | Histone deacetylase 7A
Type:PROTEIN
Mol. Mass.:101302.81
Organism:Mus musculus
Description:ChEMBL_116900
Residue:938
Sequence:
MHSPGAGCPALQPDTPGSQPQPMDLRVGQRPTVEPPPEPALLTLQHPQRLHRHLFLAGLH
QQQRSAEPMRLSMDPPMPELQGGQQEQELRQLLNKDKSKRSAVASSVVKQKLAEVILKKQ
QAALERTVHPSSPSIPYRTLEPLDTEGAARSVLSSFLPPVPSLPTEPPEHFPLRKTVSEP
NLKLRYKPKKSLERRKNPLLRKESAPPSLRRRPAETLGDSSPSSSSTPASGCSSPNDSEH
GPNPALGSEADGDRRTHSTLGPRGPVLGNPHAPLFLHHGLEPEAGGTLPSRLQPILLLDP
SVSHAPLWTVPGLGPLPFHFAQPLLTTERLSGSGLHRPLNRTRSEPLPPSATASPLLAPL
QPRQDRLKPHVQLIKPAISPPQRPAKPSEKPRLRQIPSAEDLETDGGGVGPMANDGLEHR
ESGRGPPEGRGSISLQQHQQVPPWEQQHLAGRLSQGSPGDSVLIPLAQVGHRPLSRTQSS
PAAPVSLLSPEPTCQTQVLNSSETPATGLVYDSVMLKHQCSCGDNSKHPEHAGRIQSIWS
RLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNPLSRLKLDNGKLTGLLAQRTF
VMLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELKNGFAVVRPPGHHADH
STAMGFCFFNSVAIACRQLQQHGKASKILIVDWDVHHGNGTQQTFYQDPSVLYISLHRHD
DGNFFPGSGAVDEVGTGSGEGFNVNVAWAGGLDPPMGDPEYLAAFRIVVMPIAREFAPDL
VLVSAGFDAAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGGAVVLALEGGHDLTAICDASE
ACVAALLGNKVDPLSEESWKQKPNLSAIRSLEAVVRVHRKYWGCMQRLASCPDSWLPRVP
GADAEVEAVTALASLSVGILAEDRPSERLVEEEEPMNL
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Component 8
Name:Histone deacetylase 3
Synonyms:3.5.1.98 | HD3 | HDAC3_MOUSE | Hdac3 | Histone deacetylase 3
Type:PROTEIN
Mol. Mass.:48348.05
Organism:Mus musculus
Description:ChEMBL_116900
Residue:424
Sequence:
MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCR
FHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNN
KICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEA
FYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVI
SQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTV
RNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQ
TIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDN
DKES
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Component 9
Name:Histone deacetylase 8
Synonyms:HDAC8_MOUSE | Hdac8 | Histone deacetylase
Type:PROTEIN
Mol. Mass.:41767.71
Organism:Mus musculus
Description:ChEMBL_88030
Residue:377
Sequence:
MEMPEEPANSGHSLPPVYIYSPEYVSICDSLVKVPKRASMVHSLIEAYALHKQMRIVKPK
VASMEEMATFHTDAYLQHLQKVSQEGDEDHPDSIEYGLGYDCPATEGIFDYAAAIGGGTI
TAAQCLIDGKCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFDRILYVDLDLH
HGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDMSDVGLGKGRYYSVNVPIQDGIQDEKY
YHICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYVLQWQLATLI
LGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPH
RIQQILNYIKGNLKHVV
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Component 10
Name:Histone deacetylase 11
Synonyms:3.5.1.98 | HD11 | HDA11_MOUSE | Hdac11 | Histone deacetylase 11
Type:PROTEIN
Mol. Mass.:39160.64
Organism:Mus musculus
Description:ChEMBL_116900
Residue:347
Sequence:
MPHATQLYQHVPEKRWPIVYSPRYNITFMGLEKLHPFDAGKWGKVINFLKEEKLLSDGML
VEAREASEEDLLVVHTRRYLNELKWSFVVATITEIPPVIFLPNFLVQRKVLRPLRTQTGG
TIMAGKLAVERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDL
DAHQGNGHERDFMGDKRVYIMDVYNRHIYPGDRFAKEAIRRKVELEWGTEDEEYLEKVER
NVRRSLQEHLPDVVVYNAGTDVLEGDRLGGLSISPAGIVKRDEVVFRVVRAHDIPILMVT
SGGYQKRTARIIADSILNLHDLGLIGPEFPCVSAQNSGIPLLSCAVP
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Component 11
Name:Polyamine deacetylase HDAC10
Synonyms:3.5.1.98 | HD10 | HDA10_MOUSE | Hdac10 | Histone deacetylase 10
Type:PROTEIN
Mol. Mass.:72091.98
Organism:Mus musculus
Description:ChEMBL_116900
Residue:666
Sequence:
MGTALVYHEDMTATRLLWDDPECEIECPERLTAALDGLRQRGLEERCLCLSACEASEEEL
GLVHSPEYIALVQKTQTLDKEELHALSKQYNAVYFHPDTFHCARLAAGAALQLVDAVLTG
AVHNGLALVRPPGHHSQRAAANGFCVFNNVALAAKHAKQKYGLQRILIVDWDVHHGQGIQ
YIFNDDPSVLYFSWHRYEHGSFWPFLPESDADAVGQGQGQGFTVNLPWNQVGMGNADYLA
AFLHVLLPLAFEFDPELVLVSAGFDSAIGDPEGQMQATPECFAHLTQLLQVLAGGRICAV
LEGGYHLESLAQSVCMMVQTLLGDPTPPLLGLMVPCQSALESIQSVQTAQTPYWTSLQQN
VAPVLSSSTHSPEERSLRLLGESPTCAVAEDSLSPLLDQLCLRPAPPICTAVASTVPGAA
LCLPPGVLHQEGSVLREETEAWARLHKSRFQDEDLATLGKILCLLDGIMDGQIRNAIATT
TALATAATLDVLIQRCLARRAQRVLCVALGQLDRPLDLADDGRILWLNIRGKDAAIQSMF
HFSTPLPQTTGGFLSLILGLVLPLAYGFQPDMVLMALGPAHGLQNAQAALLAAMLRSPVG
GRILAVVEEESIRLLARSLAQALHGETPPSLGPFSKATPEEIQALMFLKARLEARWKLLQ
VAAPPP
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BDBM50366962
n/a
NameBDBM50366962
Synonyms:CHEMBL1790586
TypeSmall organic molecule
Emp. Form.C30H45N5O7
Mol. Mass.587.7076
SMILESCC[C@@H](C)[C@@H]1NC(=O)[C@@H](Cc2ccc(OC)cc2)NC(=O)[C@H](CCCCCN(O)C=O)NC(=O)[C@H]2CCCCN2C1=O
Structure
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