| Reaction Details |
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 | Report a problem with these data |
| Target | Mu-type opioid receptor |
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| Ligand | BDBM50146020 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_149008 |
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| Ki | 460±n/a nM |
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| Citation |  Jinsmaa, Y; Miyazaki, A; Fujita, Y; Li, T; Fujisawa, Y; Shiotani, K; Tsuda, Y; Yokoi, T; Ambo, A; Sasaki, Y; Bryant, SD; Lazarus, LH; Okada, Y Oral bioavailability of a new class of micro-opioid receptor agonists containing 3,6-bis[Dmt-NH(CH(2))(n)]-2(1H)-pyrazinone with central-mediated analgesia. J Med Chem47:2599-610 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mu-type opioid receptor |
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| Name: | Mu-type opioid receptor |
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| Synonyms: | MOR-1 | MUOR1 | Mu-type opioid receptor (MOR) | OPIATE Mu | OPRM_RAT | Opiate non-selective | Opioid receptor B | Oprm1 | Ror-b |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 44503.11 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the mu opioid receptor. |
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| Residue: | 398 |
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| Sequence: | MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQT
GSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST
LPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRT
PRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFA
FIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYV
IIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQ
QNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP
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| BDBM50146020 |
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| n/a |
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| Name | BDBM50146020 |
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| Synonyms: | 2-Amino-N-(5-{[2-amino-3-(4-hydroxy-phenyl)-propionylamino]-methyl}-3-methyl-6-oxo-1,6-dihydro-pyrazin-2-ylmethyl)-3-(4-hydroxy-phenyl)-propionamide; dihydrochloride | CHEMBL3215757 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H32Cl2N6O5 |
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| Mol. Mass. | 567.465 |
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| SMILES | Cl.Cl.Cc1nc(CNC(=O)C(N)Cc2ccc(O)cc2)c(=O)[nH]c1CNC(=O)C(N)Cc1ccc(O)cc1 |
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| Structure | 
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