| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Phenylethanolamine N-methyltransferase |
|---|
| Ligand | BDBM50028786 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_152417 (CHEMBL763764) |
|---|
| IC50 | 193000±n/a nM |
|---|
| Citation |  Davis, DP; Borchardt, RT; Grunewald, GL Importance of the aromatic ring in adrenergic amines. 6. Nonaromatic analogues of phenylethanolamine as inhibitors of phenylethanolamine N-methyltransferase: role of pi-electronic and steric interactions. J Med Chem24:12-6 (1981) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Phenylethanolamine N-methyltransferase |
|---|
| Name: | Phenylethanolamine N-methyltransferase |
|---|
| Synonyms: | Noradrenaline N-methyltransferase | PNMT | PNMT_BOVIN | PNMTase |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 30916.97 |
|---|
| Organism: | Bos taurus (bovine) |
|---|
| Description: | n/a |
|---|
| Residue: | 283 |
|---|
| Sequence: | MSGTDRSQAAGAVPDSDPGLAAVSSAYQRFEPRAYLRNNYAPPRGDLSCPDGVGPWKLRC
LAQTFATGEVSGRTLIDIGSGPTIYQLLSACAHFEDITMTDFLEVNRQELRLWLREEPGA
FDWSVYSQHVCLIEGKGESWQEKECQLRARVKRILPIDVHRPQPLGAGGLAPLPADALVS
AFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLAVVPVREEEVR
EALVRTATRCGICARTPMPAHLQTGVDDVKGIFFTRAQKKVGV
|
|
|
|---|
| BDBM50028786 |
|---|
| n/a |
|---|
| Name | BDBM50028786 |
|---|
| Synonyms: | (endo)2-Amino-1-bicyclo[2.2.1]hept-2-yl-ethanol: Sulfate | 2-Amino-1-bicyclo[2.2.1]hept-2-yl-ethanol: Sulfate | CHEMBL40242 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C9H17NO |
|---|
| Mol. Mass. | 155.2374 |
|---|
| SMILES | NCC(O)C1CC2CCC1C2 |THB:2:4:10:8.7| |
|---|
| Structure | 
|
|---|
Search and Browse
