| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM50028641 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_54607 |
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| Ki | 0.002600±n/a nM |
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| Citation |  DeGraw, JI; Brown, VH; Tagawa, H; Kisliuk, RL; Gaumont, Y; Sirotnak, FM Synthesis and antitumor activity of 10-alkyl-10-deazaminopterins. A convenient synthesis of 10-deazaminopterin. J Med Chem25:1227-30 (1983) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | DYR_MOUSE | Dhfr |
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| Type: | Enzyme |
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| Mol. Mass.: | 21608.82 |
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| Organism: | Mus musculus (Mouse) |
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| Description: | n/a |
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| Residue: | 187 |
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| Sequence: | MVRPLNCIVAVSQNMGIGKNGDLPWPPLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFS
IPEKNRPLKDRINIVLSRELKEPPRGAHFLAKSLDDALRLIEQPELASKVDMVWIVGGSS
VYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLGKYKLLPEYPGVLSEVQEEKGIKYKF
EVYEKKD
|
|
|
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| BDBM50028641 |
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| n/a |
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| Name | BDBM50028641 |
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| Synonyms: | 2-{4-[2-(2,4-Diamino-pteridin-6-yl)-1,1-dimethyl-ethyl]-benzoylamino}-pentanedioic acid(2.5H2O) | CHEMBL20428 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H25N7O5 |
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| Mol. Mass. | 467.4778 |
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| SMILES | CC(C)(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(cc1)C(=O)NC(CCC(O)=O)C(O)=O |
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| Structure | 
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