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TargetDihydrofolate reductase
LigandBDBM50028603
Substrate/Competitorn/a
Meas. Tech.ChEBML_54897
IC50 10±n/a nM
Citation Piper, JRMcCaleb, GSMontgomery, JAKisliuk, RLGaumont, YSirotnak, FM 10-Propargylaminopterin and alkyl homologues of methotrexate as inhibitors of folate metabolism. J Med Chem25:877-80 (1982) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Dihydrofolate reductase
Name:Dihydrofolate reductase
Synonyms:DYR_LACCA | dhfR | folA
Type:PROTEIN
Mol. Mass.:18437.08
Organism:Lactobacillus casei
Description:ChEMBL_1357878
Residue:163
Sequence:
MTAFLWAQDRDGLIGKDGHLPWHLPDDLHYFRAQTVGKIMVVGRRTYESFPKRPLPERTN
VVLTHQEDYQAQGAVVVHDVAAVFAYAKQHPDQELVIAGGAQIFTAFKDDVDTLLVTRLA
GSFEGDTKMIPLNWDDFTKVSSRTVEDTNPALTHTYEVWQKKA
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  Blast E-value cutoff:
BDBM50028603
n/a
NameBDBM50028603
Synonyms:2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-prop-2-ynyl-amino]-benzoylamino}-pentanedioic acid | CHEMBL166915
TypeSmall organic molecule
Emp. Form.C22H22N8O5
Mol. Mass.478.4607
SMILESNc1nc(N)c2nc(CN(CC#C)c3ccc(cc3)C(=O)NC(CCC(O)=O)C(O)=O)cnc2n1
Structure
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