Reaction Details |
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Target | Adenosine deaminase |
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Ligand | BDBM22925 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_31098 (CHEMBL640454) |
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Ki | 0.00250±n/a nM |
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Citation | Showalter, HD; Putt, SR; Borondy, PE; Shillis, JL Adenosine deaminase inhibitors. Synthesis and biological evaluation of (+/-)-3,6,7,8-tetrahydro-3-[(2-hydroxyethoxy)methyl]imidazo[4,5-d] [1,3]diazepin-8-ol and some selected C-5 homologues of pentostatin. J Med Chem26:1478-82 (1983) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Adenosine deaminase |
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Name: | Adenosine deaminase |
Synonyms: | ADA | ADA1 | ADA_HUMAN | Adenosine aminohydrolase |
Type: | Enzyme |
Mol. Mass.: | 40759.44 |
Organism: | Homo sapiens (Human) |
Description: | Human recombinant ADA was expressed and purified from an ADA-deficient bacterial strain. |
Residue: | 363 |
Sequence: | MAQTPAFDKPKVELHVHLDGSIKPETILYYGRRRGIALPANTAEGLLNVIGMDKPLTLPD
FLAKFDYYMPAIAGCREAIKRIAYEFVEMKAKEGVVYVEVRYSPHLLANSKVEPIPWNQA
EGDLTPDEVVALVGQGLQEGERDFGVKARSILCCMRHQPNWSPKVVELCKKYQQQTVVAI
DLAGDETIPGSSLLPGHVQAYQEAVKSGIHRTVHAGEVGSAEVVKEAVDILKTERLGHGY
HTLEDQALYNRLRQENMHFEICPWSSYLTGAWKPDTEHAVIRLKNDQANYSLNTDDPLIF
KSTLDTDYQMTKRDMGFTEEEFKRLNINAAKSSFLPEDEKRELLDLLYKAYGMPPSASAG
QNL
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BDBM22925 |
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n/a |
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Name | BDBM22925 |
Synonyms: | (8R)-3-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H,6H,7H,8H-imidazo[4,5-d][1,3]diazepin-8-ol | Covidarabine | Deoxycoformycin | Nipent | Pentostatin |
Type | Nucleoside or nucleotide |
Emp. Form. | C11H16N4O4 |
Mol. Mass. | 268.2691 |
SMILES | OC[C@H]1O[C@H](C[C@@H]1O)n1cnc2[C@H](O)CNC=Nc12 |c:17| |
Structure |
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