| Reaction Details |
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 | Report a problem with these data |
| Target | Alpha-2A adrenergic receptor |
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| Ligand | BDBM50026973 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_33039 |
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| Ki | 330±n/a nM |
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| Citation |  Remy, DC; Britcher, SF; King, SW; Anderson, PS; Hunt, CA; Randall, WC; Bélanger, P; Atkinson, JG; Girard, Y; Rooney, CS; Fuentes, JJ; Totaro, JA; Robinson, JL; Risley, EA; Williams, M Synthesis and receptor binding studies relevant to the neuroleptic activities of some 1-methyl-4-piperidylidene-9-substituted-pyrrolo[2,1-b][3]benzazepine derivatives. J Med Chem26:974-80 (1983) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Alpha-2A adrenergic receptor |
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| Name: | Alpha-2A adrenergic receptor |
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| Synonyms: | ADA2A_BOVIN | ADRA2A | Alpha-2A adrenergic receptor | Alpha-2A adrenoceptor | Alpha-2A adrenoreceptor | Alpha-2AAR | Alpha-2D adrenergic receptor | Alpha-2Da adrenergic receptor | Cerebral cortex alpha adrenergic receptor | adrenergic Alpha2A | adrenergic Alpha2D |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 49275.13 |
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| Organism: | BOVINE |
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| Description: | adrenergic Alpha2 0 BOVINE::Q28838 |
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| Residue: | 452 |
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| Sequence: | MGSLQPDAGNASWNGTEAPGGGARATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFT
SRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSS
IVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISFEKKRGRSG
QPSAEPRCEINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDATA
AELPGSAERRPNGLGPERGGVGPVGAEVESLQVQLNGAPGEPAPAGAGADALDLEESSSS
EHAERPPGSRRSERGPRAKGKARASQVKPGDSLPRRGPGATGLGAPTAGPAEERSGGGAK
ASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAIGCPVPPTLFKFFFWFGYCN
SSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV
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| BDBM50026973 |
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| n/a |
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| Name | BDBM50026973 |
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| Synonyms: | 11-(1-Methyl-piperidin-4-ylidene)-9-trifluoromethylsulfanyl-6,11-dihydro-5H-benzo[d]pyrrolo[1,2-a]azepine | CHEMBL368475 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H21F3N2S |
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| Mol. Mass. | 378.454 |
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| SMILES | [#6]-[#7]-1-[#6]-[#6]\[#6](-[#6]-[#6]-1)=[#6]-1/c2cccn2-[#6]-[#6]-c2ccc(-[#16]C(F)(F)F)cc-12 |
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| Structure | 
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