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TargetThymidylate synthase/GAR transformylase/AICAR transformylase
LigandBDBM50028106
Substrate/Competitorn/a
Meas. Tech.ChEMBL_209657
Ki 150000±n/a nM
Citation Srinivasan AAmarnath VBroom ADZou FCCheng YC A potent multisubstrate analogue inhibitor of human thymidylate synthetase. J Med Chem 27:1710-7 (1985) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Thymidylate synthase/GAR transformylase/AICAR transformylase
Name:Thymidylate synthase/GAR transformylase/AICAR transformylase
Synonyms:TS | TSase | Thymidylate synthase (TS)
Type:Enzyme
Mol. Mass.:35718.07
Organism:Homo sapiens (Human)
Description:n/a
Residue:313
Sequence:
MPVAGSELPRRPLPPAAQERDAEPRPPHGELQYLGQIQHILRCGVRKDDRTGTGTLSVFG
MQARYSLRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVKIWDANGSRDFLDS
LGFSTREEGDLGPVYGFQWRHFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDDRRIIMC
AWNPRDLPLMALPPCHALCQFYVVNSELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHI
TGLKPGDFIHTLGDAHIYLNHIEPLKIQLQREPRPFPKLRILRKVEKIDDFKAEDFQIEG
YNPHPTIKMEMAV
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  Blast E-value cutoff:
BDBM50028106
n/a
NameBDBM50028106
Synonyms:CHEMBL46945 | diethyl 2-{4-[2-amino-4-oxo-3,4,5,6,7,8-hexahydropyrido[3,2-d]pyrimidin-6-ylmethyl(nitroso)amino]phenylcarboxamido}pentanedioate
TypeSmall organic molecule
Emp. Form.C24H31N7O7
Mol. Mass.529.5456
SMILESCCOC(=O)CCC(NC(=O)c1ccc(cc1)N(CC1CCc2nc(N)[nH]c(=O)c2N1)N=O)C(=O)OCC
Structure
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