| Reaction Details |
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 | Report a problem with these data |
| Target | Renin |
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| Ligand | BDBM50025940 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_196268 |
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| IC50 | 64±n/a nM |
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| Citation |  Boger, J; Payne, LS; Perlow, DS; Lohr, NS; Poe, M; Blaine, EH; Ulm, EH; Schorn, TW; LaMont, BI; Lin, TY Renin inhibitors. Syntheses of subnanomolar, competitive, transition-state analogue inhibitors containing a novel analogue of statine. J Med Chem28:1779-90 (1986) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Renin |
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| Name: | Renin |
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| Synonyms: | Angiotensinogenase | REN | RENI_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 45058.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 406 |
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| Sequence: | MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
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| BDBM50025940 |
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| n/a |
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| Name | BDBM50025940 |
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| Synonyms: | 4-[2-(2-Acetylamino-3-phenyl-propionylamino)-3-(1H-imidazol-4-yl)-propionylamino]-3-hydroxy-5-phenyl-pentanoic acid [1-(1-carbamoyl-2-phenyl-ethylcarbamoyl)-3-methyl-butyl]-amide | CHEMBL3144413 |
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| Type | Small organic molecule |
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| Emp. Form. | C43H54N8O7 |
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| Mol. Mass. | 794.9383 |
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| SMILES | CC(C)C[C@H](NC(=O)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O |r| |
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| Structure | 
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