Reaction Details | |||
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Target | Mu-type opioid receptor | ||
Ligand | BDBM50021255 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEBML_148683 | ||
IC50 | 6.4±n/a nM | ||
Citation | Archer, S; Michael, J; Osei-Gyimah, P; Seyed-Mozaffari, A; Zukin, RS; Maneckjee, R; Simon, EJ; Gioannini, TL Hybromet: a ligand for purifying opioid receptors. J Med Chem28:1950-3 (1986) [PubMed] | ||
More Info.: | Get all data from this article, Assay Method | ||
Mu-type opioid receptor | |||
Name: | Mu-type opioid receptor | ||
Synonyms: | MOR-1 | MUOR1 | Mu-type opioid receptor (MOR) | OPIATE Mu | OPRM_RAT | Opiate non-selective | Opioid receptor B | Oprm1 | Ror-b | ||
Type: | G Protein-Coupled Receptor (GPCR) | ||
Mol. Mass.: | 44503.11 | ||
Organism: | Rattus norvegicus (rat) | ||
Description: | Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the mu opioid receptor. | ||
Residue: | 398 | ||
Sequence: |
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BDBM50021255 | |||
n/a | |||
Name | BDBM50021255 | ||
Synonyms: | 2-[11,15-dimethoxy-3-methyl-(1R,14R,15R)-13-oxa-3-azahexacyclo[13.2.2.12,8.01,6.06,14.07,12]icosa-7,9,11,18-tetraen-16-yl]-4-[4-(2-propynyloxy)phenyl]-2-butanol | CHEMBL301038 | ||
Type | Small organic molecule | ||
Emp. Form. | C34H39NO5 | ||
Mol. Mass. | 541.6772 | ||
SMILES | COc1ccc2CC3N(C)CCC45[C@@H](Oc1c24)[C@@]1(OC)C=C[C@@]35C[C@@H]1[C@@](C)(O)CCc1ccc(OCC#C)cc1 |wU:25.32,wD:13.13,22.24,24.30,25.33,17.20,c:23,THB:9:8:22:16.5.6,15:16:22:8.11.10,21:22:16.5.6:8.11.10,(-2.56,-8.78,;-1.02,-8.75,;-.27,-7.4,;-1.07,-6.07,;-.32,-4.74,;1.22,-4.7,;1.96,-3.36,;3.5,-3.34,;4.25,-1.99,;5.58,-1.21,;2.69,-1.98,;2.76,-4.64,;3.53,-5.98,;4.32,-7.3,;2.74,-8.22,;1.27,-7.38,;2.01,-6.03,;5.84,-7.29,;6.45,-8.7,;5.51,-9.92,;5.44,-5.79,;4.67,-6.12,;4.29,-4.65,;5.82,-4.63,;6.6,-5.95,;8.14,-5.93,;8.13,-4.39,;8.13,-7.47,;9.67,-5.93,;10.45,-7.26,;11.99,-7.26,;12.75,-5.91,;14.29,-5.91,;15.07,-7.24,;16.6,-7.23,;17.37,-5.9,;18.91,-5.89,;20.45,-5.89,;14.3,-8.57,;12.76,-8.59,)| | ||
Structure |