| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Thromboxane-A synthase |
|---|
| Ligand | BDBM50026486 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_207779 |
|---|
| IC50 | 51.0±n/a nM |
|---|
| Citation |  Kato, K; Ohkawa, S; Terao, S; Terashita, Z; Nishikawa, K Thromboxane synthetase inhibitors (TXSI). Design, synthesis, and evaluation of a novel series of omega-pyridylalkenoic acids. J Med Chem28:287-94 (1985) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Thromboxane-A synthase |
|---|
| Name: | Thromboxane-A synthase |
|---|
| Synonyms: | CYP5 | CYP5A1 | Cytochrome P450 5A1 | P450 TxA2 | TBXAS1 | THAS_HUMAN | TXA synthase | TXAS | TXS | Thromboxane A2 Synthase | Thromboxane A2 Synthase (P450 TxA2) | Thromboxane Alpha | Thromboxane prostanoid | Thromboxane synthase | Thromboxane-A synthase |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 60524.67 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P24557 |
|---|
| Residue: | 533 |
|---|
| Sequence: | MEALGFLKLEVNGPMVTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFR
QGFWESQMELRKLYGPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKSV
ADSVLFLRDKRWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQR
CYCNYTTDVVASVAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPLA
RILPNKNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIV
RDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATN
PDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEV
LGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCL
GVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVYIKIVSR
|
|
|
|---|
| BDBM50026486 |
|---|
| n/a |
|---|
| Name | BDBM50026486 |
|---|
| Synonyms: | (Z)-7-Phenyl-7-pyridin-3-yl-hept-6-enoic acid | 7-Phenyl-7-pyridin-3-yl-hept-6-enoic acid | CHEMBL28196 | Isbogrel |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H19NO2 |
|---|
| Mol. Mass. | 281.349 |
|---|
| SMILES | OC(=O)CCCC\C=C(\c1ccccc1)c1cccnc1 |
|---|
| Structure | 
|
|---|
Search and Browse
