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TargetDihydrofolate reductase
LigandBDBM50026311
Substrate/Competitorn/a
Meas. Tech.ChEMBL_54556 (CHEMBL664872)
Ki 5.2±n/a nM
Citation Kuyper, LFRoth, BBaccanari, DPFerone, RBeddell, CRChampness, JNStammers, DKDann, JGNorrington, FEBaker, DJ Receptor-based design of dihydrofolate reductase inhibitors: comparison of crystallographically determined enzyme binding with enzyme affinity in a series of carboxy-substituted trimethoprim analogues. J Med Chem28:303-11 (1985) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Dihydrofolate reductase
Name:Dihydrofolate reductase
Synonyms:Dihydrofolate reductase (F31V) | dfrA17
Type:n/a
Mol. Mass.:17532.46
Organism:Escherichia coli
Description:n/a
Residue:157
Sequence:
MKISLISAVSESGVIGSGPDIPWSVKGEQLLFKALTYNQWLLVGRKTFDSMGVLPNRKYA
VVSKNGISSSNENVLVFPSIENALKELSKVTDHVYVSGGGQIYNSLIEKADIIHLSTVHV
EVEGDIKFPIMPENFNLVFEQFFMSNINYTYQIWKKG
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BDBM50026311
n/a
NameBDBM50026311
Synonyms:4-[4-(2,4-Diamino-pyrimidin-5-ylmethyl)-2,6-dimethoxy-phenoxy]-butyric acid | CHEMBL320596
TypeSmall organic molecule
Emp. Form.C17H22N4O5
Mol. Mass.362.3804
SMILESCOc1cc(Cc2cnc(N)nc2N)cc(OC)c1OCCCC(O)=O
Structure
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