Reaction Details |
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Target | Dihydrofolate reductase |
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Ligand | BDBM50026318 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_54542 (CHEMBL664859) |
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Ki | 0.050000±n/a nM |
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Citation | Kuyper, LF; Roth, B; Baccanari, DP; Ferone, R; Beddell, CR; Champness, JN; Stammers, DK; Dann, JG; Norrington, FE; Baker, DJ Receptor-based design of dihydrofolate reductase inhibitors: comparison of crystallographically determined enzyme binding with enzyme affinity in a series of carboxy-substituted trimethoprim analogues. J Med Chem28:303-11 (1985) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Dihydrofolate reductase |
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Name: | Dihydrofolate reductase |
Synonyms: | Dihydrofolate reductase (F31V) | dfrA17 |
Type: | n/a |
Mol. Mass.: | 17532.46 |
Organism: | Escherichia coli |
Description: | n/a |
Residue: | 157 |
Sequence: | MKISLISAVSESGVIGSGPDIPWSVKGEQLLFKALTYNQWLLVGRKTFDSMGVLPNRKYA
VVSKNGISSSNENVLVFPSIENALKELSKVTDHVYVSGGGQIYNSLIEKADIIHLSTVHV
EVEGDIKFPIMPENFNLVFEQFFMSNINYTYQIWKKG
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BDBM50026318 |
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n/a |
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Name | BDBM50026318 |
Synonyms: | 7-[5-(2,4-Diamino-pyrimidin-5-ylmethyl)-2,3-dimethoxy-phenoxy]-heptanoic acid | CHEMBL274430 | TCMDC-137630 |
Type | Small organic molecule |
Emp. Form. | C20H28N4O5 |
Mol. Mass. | 404.4601 |
SMILES | COc1cc(Cc2cnc(N)nc2N)cc(OCCCCCCC(O)=O)c1OC |
Structure |
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