| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine N-methyltransferase |
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| Ligand | BDBM50026331 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_87234 |
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| Ki | 10400±n/a nM |
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| Citation |  Houston, DM; Matuszewska, B; Borchardt, RT Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 10. Base- and amino acid modified analogues of S-aristeromycinyl-L-homocysteine. J Med Chem28:478-82 (1985) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine N-methyltransferase |
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| Name: | Histamine N-methyltransferase |
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| Synonyms: | HMT | HNMT | HNMT_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 33287.63 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_87234 |
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| Residue: | 292 |
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| Sequence: | MASSMRSLFSDHGKYVESFRRFLNHSTEHQCMQEFMDKKLPGIIGRIGDTKSEIKILSIG
GGAGEIDLQILSKVQAQYPGVCINNEVVEPSAEQIAKYKELVAKTSNLENVKFAWHKETS
SEYQSRMLEKKELQKWDFIHMIQMLYYVKDIPATLKFFHSLLGTNAKMLIIVVSGSSGWD
KLWKKYGSRFPQDDLCQYITSDDLTQMLDNLGLKYECYDLLSTMDISDCFIDGNENGDLL
WDFLTETCNFNATAPPDLRAELGKDLQEPEFSAKKEGKVLFNNTLSFIVIEA
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| BDBM50026331 |
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| n/a |
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| Name | BDBM50026331 |
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| Synonyms: | 2-Amino-4-[4-(6-amino-purin-9-yl)-2,3-dihydroxy-cyclopentylmethylsulfanyl]-butyric acid | CHEMBL342283 | L-2-Amino-4-[5-(6-amino-purin-9-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethylsulfanyl]-butyric acid |
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| Type | Small organic molecule |
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| Emp. Form. | C15H22N6O4S |
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| Mol. Mass. | 382.438 |
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| SMILES | NC(CCSCC1CC(C(O)C1O)n1cnc2c(N)ncnc12)C(O)=O |
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| Structure | 
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