| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Phenylethanolamine N-methyltransferase |
|---|
| Ligand | BDBM50026331 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_152425 (CHEMBL763772) |
|---|
| Ki | 7590±n/a nM |
|---|
| Citation |  Houston, DM; Matuszewska, B; Borchardt, RT Potential inhibitors of S-adenosylmethionine-dependent methyltransferases. 10. Base- and amino acid modified analogues of S-aristeromycinyl-L-homocysteine. J Med Chem28:478-82 (1985) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Phenylethanolamine N-methyltransferase |
|---|
| Name: | Phenylethanolamine N-methyltransferase |
|---|
| Synonyms: | Noradrenaline N-methyltransferase | PNMT | PNMT_BOVIN | PNMTase |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 30916.97 |
|---|
| Organism: | Bos taurus (bovine) |
|---|
| Description: | n/a |
|---|
| Residue: | 283 |
|---|
| Sequence: | MSGTDRSQAAGAVPDSDPGLAAVSSAYQRFEPRAYLRNNYAPPRGDLSCPDGVGPWKLRC
LAQTFATGEVSGRTLIDIGSGPTIYQLLSACAHFEDITMTDFLEVNRQELRLWLREEPGA
FDWSVYSQHVCLIEGKGESWQEKECQLRARVKRILPIDVHRPQPLGAGGLAPLPADALVS
AFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLAVVPVREEEVR
EALVRTATRCGICARTPMPAHLQTGVDDVKGIFFTRAQKKVGV
|
|
|
|---|
| BDBM50026331 |
|---|
| n/a |
|---|
| Name | BDBM50026331 |
|---|
| Synonyms: | 2-Amino-4-[4-(6-amino-purin-9-yl)-2,3-dihydroxy-cyclopentylmethylsulfanyl]-butyric acid | CHEMBL342283 | L-2-Amino-4-[5-(6-amino-purin-9-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethylsulfanyl]-butyric acid |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C15H22N6O4S |
|---|
| Mol. Mass. | 382.438 |
|---|
| SMILES | NC(CCSCC1CC(C(O)C1O)n1cnc2c(N)ncnc12)C(O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
