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TargetDihydrofolate reductase
LigandBDBM50367251
Substrate/Competitorn/a
Meas. Tech.ChEBML_53934
IC50 49000±n/a nM
Citation Taylor ECHarrington PJFletcher SRBeardsley GPMoran RG Synthesis of the antileukemic agents 5,10-dideazaaminopterin and 5,10-dideaza-5,6,7,8-tetrahydroaminopterin. J Med Chem 28:914-21 (1985) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Dihydrofolate reductase
Name:Dihydrofolate reductase
Synonyms:n/a
Type:PROTEIN
Mol. Mass.:18437.08
Organism:Lactobacillus casei
Description:ChEMBL_1357878
Residue:163
Sequence:
MTAFLWAQDRDGLIGKDGHLPWHLPDDLHYFRAQTVGKIMVVGRRTYESFPKRPLPERTN
VVLTHQEDYQAQGAVVVHDVAAVFAYAKQHPDQELVIAGGAQIFTAFKDDVDTLLVTRLA
GSFEGDTKMIPLNWDDFTKVSSRTVEDTNPALTHTYEVWQKKA
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  Blast E-value cutoff:
BDBM50367251
n/a
NameBDBM50367251
Synonyms:CHEMBL350097
TypeSmall organic molecule
Emp. Form.C21H21N5O6
Mol. Mass.439.4213
SMILESNc1nc2ncc(CCc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)cc2c(=O)[nH]1
Structure
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