| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Thymidylate synthase |
|---|
| Ligand | BDBM50367251 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_210167 |
|---|
| IC50 | 77000±n/a nM |
|---|
| Citation |  Taylor, EC; Harrington, PJ; Fletcher, SR; Beardsley, GP; Moran, RG Synthesis of the antileukemic agents 5,10-dideazaaminopterin and 5,10-dideaza-5,6,7,8-tetrahydroaminopterin. J Med Chem28:914-21 (1985) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Thymidylate synthase |
|---|
| Name: | Thymidylate synthase |
|---|
| Synonyms: | TSase | TYSY_LACCA | Thymidylate Synthase (TS) | Thymidylate synthase | thyA |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 36576.54 |
|---|
| Organism: | Lactobacillus casei |
|---|
| Description: | n/a |
|---|
| Residue: | 316 |
|---|
| Sequence: | MLEQPYLDLAKKVLDEGHFKPDRTHTGTYSIFGHQMRFDLSKGFPLLTTKKVPFGLIKSE
LLWFLHGDTNIRFLLQHRNHIWDEWAFEKWVKSDEYHGPDMTDFGHRSQKDPEFAAVYHE
EMAKFDDRVLHDDAFAAKYGDLGLVYGSQWRAWHTSKGDTIDQLGDVIEQIKTHPYSRRL
IVSAWNPEDVPTMALPPCHTLYQFYVNDGKLSLQLYQRSADIFLGVPFNIASYALLTHLV
AHECGLEVGEFIHTFGDAHLYVNHLDQIKEQLSRTPRPAPTLQLNPDKHDIFDFDMKDIK
LLNYDPYPAIKAPVAV
|
|
|
|---|
| BDBM50367251 |
|---|
| n/a |
|---|
| Name | BDBM50367251 |
|---|
| Synonyms: | CHEMBL350097 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H21N5O6 |
|---|
| Mol. Mass. | 439.4213 |
|---|
| SMILES | Nc1nc2ncc(CCc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)cc2c(=O)[nH]1 |
|---|
| Structure | 
|
|---|
Search and Browse
