Reaction Details | |||
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Target | Dihydrofolate reductase | ||
Ligand | BDBM50003896 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEBML_53934 | ||
IC50 | 560000±n/a nM | ||
Citation | Taylor, EC; Harrington, PJ; Fletcher, SR; Beardsley, GP; Moran, RG Synthesis of the antileukemic agents 5,10-dideazaaminopterin and 5,10-dideaza-5,6,7,8-tetrahydroaminopterin. J Med Chem28:914-21 (1985) [PubMed] | ||
More Info.: | Get all data from this article, Assay Method | ||
Dihydrofolate reductase | |||
Name: | Dihydrofolate reductase | ||
Synonyms: | DYR_LACCA | dhfR | folA | ||
Type: | PROTEIN | ||
Mol. Mass.: | 18437.08 | ||
Organism: | Lactobacillus casei | ||
Description: | ChEMBL_1357878 | ||
Residue: | 163 | ||
Sequence: |
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BDBM50003896 | |||
n/a | |||
Name | BDBM50003896 | ||
Synonyms: | (DDATHF) 5,10-Dideazatetrahydrofolic acid2-{4-[2-(2-Amino-4-oxo-3,4,5,6,7,8-hexahydro-pyrido[2,3-d]pyrimidin-6-yl)-ethyl]-benzoylamino}-pentanedioic acid | 2-{(S)-4-[2-(2-Amino-4-oxo-3,4,5,6,7,8-hexahydro-pyrido[2,3-d]pyrimidin-6-yl)-ethyl]-benzoylamino}-pentanedioic acid | 2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-pentanedioic acid | 2-{4-[2-(2-Amino-4-hydroxy-5,6,7,8-tetrahydro-pyrido[2,3-d]pyrimidin-6-yl)-ethyl]-benzoylamino}-pentanedioic acid | 2-{4-[2-(2-Amino-4-oxo-3,4,5,6,7,8-hexahydro-pyrido[2,3-d]pyrimidin-6-yl)-ethyl]-benzoylamino}-pentanedioic acid | CHEMBL170101 | ||
Type | Small organic molecule | ||
Emp. Form. | C21H25N5O6 | ||
Mol. Mass. | 443.4531 | ||
SMILES | Nc1nc2NCC(CCc3ccc(cc3)C(=O)NC(CCC(O)=O)C(O)=O)Cc2c(=O)[nH]1 | ||
Structure |