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TargetAldo-keto reductase family 1 member B1
LigandBDBM50049730
Substrate/Competitorn/a
Meas. Tech.ChEBML_31924
IC50 10±n/a nM
Citation DeRuiter, JBrubaker, ANWhitmer, WLStein, JL Synthesis and aldose reductase inhibitory activity of substituted 2-oxoquinoline-1-acetic acid derivatives. J Med Chem29:2024-8 (1986) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Aldo-keto reductase family 1 member B1
Name:Aldo-keto reductase family 1 member B1
Synonyms:ALDR_RAT | Akr1b1 | Akr1b4 | Aldose reductase | Aldr1
Type:PROTEIN
Mol. Mass.:35797.87
Organism:Rattus norvegicus
Description:ChEMBL_1512484
Residue:316
Sequence:
MASHLELNNGTKMPTLGLGTWKSPPGQVTEAVKVAIDMGYRHIDCAQVYQNEKEVGVALQ
EKLKEQVVKRQDLFIVSKLWCTFHDQSMVKGACQKTLSDLQLDYLDLYLIHWPTGFKPGP
DYFPLDASGNVIPSDTDFVDTWTAMEQLVDEGLVKAIGVSNFNPLQIERILNKPGLKYKP
AVNQIECHPYLTQEKLIEYCHCKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKEIAAK
YNKTTAQVLIRFPIQRNLVVIPKSVTPARIAENFKVFDFELSNEDMATLLSYNRNWRVCA
LMSCAKHKDYPFHAEV
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  Blast E-value cutoff:
BDBM50049730
n/a
NameBDBM50049730
Synonyms:2-(5-(2-methyl-3-phenylallylidene)-4-oxo-2-thioxothiazolidin-3-yl)acetic acid | CHEMBL56337 | Epalrestat | {5-[(E)-2-Methyl-3-phenyl-prop-2-en-(Z)-ylidene]-4-oxo-2-thioxo-thiazolidin-3-yl}-acetic acid
TypeSmall organic molecule
Emp. Form.C15H13NO3S2
Mol. Mass.319.399
SMILESC\C(\C=C1/SC(=S)N(CC(O)=O)C1=O)=C/c1ccccc1
Structure
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