| Reaction Details |
|---|
 | Report a problem with these data |
| Target | 3-oxo-5-alpha-steroid 4-dehydrogenase 1/2 |
|---|
| Ligand | BDBM8885 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_204598 (CHEMBL813360) |
|---|
| IC50 | 1900±n/a nM |
|---|
| Citation |  Rasmusson, GH; Reynolds, GF; Steinberg, NG; Walton, E; Patel, GF; Liang, T; Cascieri, MA; Cheung, AH; Brooks, JR; Berman, C Azasteroids: structure-activity relationships for inhibition of 5 alpha-reductase and of androgen receptor binding. J Med Chem29:2298-315 (1986) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| 3-oxo-5-alpha-steroid 4-dehydrogenase 1/2 |
|---|
| Name: | 3-oxo-5-alpha-steroid 4-dehydrogenase 1/2 |
|---|
| Synonyms: | Steroid 5-alpha-reductase |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | n/a |
|---|
| Description: | ASSAY_ID of ChEMBL is 204723 |
|---|
| Components: | This complex has 2 components. |
|---|
| Component 1 |
| Name: | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 |
|---|
| Synonyms: | S5A1_RAT | Srd5a1 | Steroid 5-alpha-reductase | Steroid 5-alpha-reductase 1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 29788.29 |
|---|
| Organism: | Rattus norvegicus |
|---|
| Description: | ChEMBL_1441437 |
|---|
| Residue: | 259 |
|---|
| Sequence: | MVPLMELDELCLLDMLVYLEGFMAFVSIVGLRSVGSPYGRYSPQWPGIRVPARPAWFIQE
LPSMAWPLYEYIRPAAARLGNLPNRVLLAMFLIHYVQRTLVFPVLIRGGKPTLLVTFVLA
FLFCTFNGYVQSRYLSQFAVYAEDWVTHPCFLTGFALWLVGMVINIHSDHILRNLRKPGE
TGYKIPRGGLFEYVSAANYFGELVEWCGFALASWSLQGVVFALFTLSTLLTRAKQHHQWY
HEKFEDYPKSRKILIPFVL
|
|
|
|---|
| Component 2 |
| Name: | 3-oxo-5-alpha-steroid 4-dehydrogenase 2 |
|---|
| Synonyms: | S5A2_RAT | Srd5a2 | Steroid 5-alpha-reductase | Steroid 5-alpha-reductase 2 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 28784.15 |
|---|
| Organism: | Rattus norvegicus |
|---|
| Description: | ChEMBL_205054 |
|---|
| Residue: | 254 |
|---|
| Sequence: | MQIVCHQVPVLAGSATLATMGTLILCLGKPASYGKHTESVSSGVPFLPARIAWFLQELPS
FVVSVGMLAWQPRSLFGPPGNVLLALFSAHYFHRTFIYSLLTRGRPFPAVLFLRATAFCI
GNGLLQAYYLVYCAEYPEEWYTDVRFSFGVFLFILGMGINIHSDYTLRQLRKPGEVIYRI
PRGGLFTYVSGANFLGEIIEWIGYALATWSVPAFAFAFFTLCFLGMQAFYHHRFYLKMFK
DYPKSRKALIPFIF
|
|
|
|---|
| BDBM8885 |
|---|
| n/a |
|---|
| Name | BDBM8885 |
|---|
| Synonyms: | (1S,2R,10R,11S,14S,15S)-14-hydroxy-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one | 17beta-Hydroxyandrost-4-en-3-one | Testosterone | Testosterone, 1 | US9682960, Testosterone |
|---|
| Type | Steroid |
|---|
| Emp. Form. | C19H28O2 |
|---|
| Mol. Mass. | 288.4244 |
|---|
| SMILES | [H][C@@]12CC[C@H](O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12C |r,t:18| |
|---|
| Structure | 
|
|---|
Search and Browse
