Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetS-adenosylmethionine synthase isoform type-1/type-2
LigandBDBM50367328
Substrate/Competitorn/a
Meas. Tech.ChEMBL_104959 (CHEMBL715641)
Ki 38000±n/a nM
Citation Kappler, FHai, TTCotter, RJHyver, KJHampton, A Isozyme-specific enzyme inhibitors. 11. L-homocysteine-ATP S-C5' covalent adducts as inhibitors of rat methionine adenosyltransferases. J Med Chem29:1030-8 (1986) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
S-adenosylmethionine synthase isoform type-1/type-2
Name:S-adenosylmethionine synthase isoform type-1/type-2
Synonyms:S-adenosylmethionine synthetase (MAT 1 and MAT 2)
Type:n/a
Mol. Mass.:n/a
Description:ASSAY_ID of ChEMBL is 104961
Components:This complex has 2 components.
Component 1
Name:S-adenosylmethionine synthase isoform type-1
Synonyms:AdoMet synthetase 1 | Ams1 | MAT 1 | MAT-I/III | METK1_RAT | Mat1a | Methionine adenosyltransferase 1 | Methionine adenosyltransferase I/III | S-adenosylmethionine synthetase (MAT 1 and MAT 2) | S-adenosylmethionine synthetase alpha and beta forms | S-adenosylmethionine synthetase isoform type-1
Type:PROTEIN
Mol. Mass.:43692.87
Organism:Rattus norvegicus
Description:ChEMBL_11027
Residue:397
Sequence:
MNGPVDGLCDHSLSEEGAFMFTSESVGEGHPDKICDQISDAVLDAHLKQDPNAKVACETV
CKTGMVLLCGEITSMAMIDYQRVVRDTIKHIGYDDSAKGFDFKTCNVLVALEQQSPDIAQ
CVHLDRNEEDVGAGDQGLMFGYATDETEECMPLTIVLAHKLNTRMADLRRSGVLPWLRPD
SKTQVTVQYVQDNGAVIPVRVHTIVISVQHNEDITLEAMREALKEQVIKAVVPAKYLDED
TIYHLQPSGRFVIGGPQGDAGVTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAAR
WVAKSLVKAGLCRRVLVQVSYAIGVAEPLSISIFTYGTSKKTERDELLEVVNKNFDLRPG
VIVRDLDLKKPIYQKTACYGHFGRSEFPWEVPKKLVF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
Component 2
Name:S-adenosylmethionine synthase isoform type-2
Synonyms:AdoMet synthetase 2 | Ams2 | MAT 2 | MAT-II | METK2_RAT | Mat2a | Methionine adenosyltransferase 2 | Methionine adenosyltransferase II | S-Adenosylmethionine Synthase (AdoMet) | S-adenosylmethionine synthetase (MAT 1 and MAT 2) | S-adenosylmethionine synthetase gamma form | S-adenosylmethionine synthetase isoform type-2
Type:PROTEIN
Mol. Mass.:43713.68
Organism:Rattus norvegicus
Description:ChEMBL_105118
Residue:395
Sequence:
MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQINDAVLDAHLQQDPDAKVACETVA
KTGMILLAGEITSRAAIDYQKVVREAIKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQG
VHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDS
KTQVTVQYMQDRGAVIPIRVHTIVISVQHDEEVCLDEMRDALKEKLIKAVVPAKYLDEDT
IYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARW
VAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKNNFDLRPGVI
VRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50367328
n/a
NameBDBM50367328
Synonyms:CHEMBL1791415
TypeSmall organic molecule
Emp. Form.C15H26N7O13P3S
Mol. Mass.637.392
SMILESNC(CCSC(CP(O)(=O)OP(O)(=O)NP(O)(O)=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: