Reaction Details |
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Target | S-adenosylmethionine synthase isoform type-1/type-2 |
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Ligand | BDBM50367328 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_104958 (CHEMBL715640) |
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Ki | 11000±n/a nM |
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Citation | Kappler, F; Hai, TT; Cotter, RJ; Hyver, KJ; Hampton, A Isozyme-specific enzyme inhibitors. 11. L-homocysteine-ATP S-C5' covalent adducts as inhibitors of rat methionine adenosyltransferases. J Med Chem29:1030-8 (1986) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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S-adenosylmethionine synthase isoform type-1/type-2 |
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Name: | S-adenosylmethionine synthase isoform type-1/type-2 |
Synonyms: | S-adenosylmethionine synthetase (MAT 1 and MAT 2) |
Type: | n/a |
Mol. Mass.: | n/a |
Description: | ASSAY_ID of ChEMBL is 104961 |
Components: | This complex has 2 components. |
Component 1 |
Name: | S-adenosylmethionine synthase isoform type-1 |
Synonyms: | AdoMet synthetase 1 | Ams1 | MAT 1 | MAT-I/III | METK1_RAT | Mat1a | Methionine adenosyltransferase 1 | Methionine adenosyltransferase I/III | S-adenosylmethionine synthetase (MAT 1 and MAT 2) | S-adenosylmethionine synthetase alpha and beta forms | S-adenosylmethionine synthetase isoform type-1 |
Type: | PROTEIN |
Mol. Mass.: | 43692.87 |
Organism: | Rattus norvegicus |
Description: | ChEMBL_11027 |
Residue: | 397 |
Sequence: | MNGPVDGLCDHSLSEEGAFMFTSESVGEGHPDKICDQISDAVLDAHLKQDPNAKVACETV
CKTGMVLLCGEITSMAMIDYQRVVRDTIKHIGYDDSAKGFDFKTCNVLVALEQQSPDIAQ
CVHLDRNEEDVGAGDQGLMFGYATDETEECMPLTIVLAHKLNTRMADLRRSGVLPWLRPD
SKTQVTVQYVQDNGAVIPVRVHTIVISVQHNEDITLEAMREALKEQVIKAVVPAKYLDED
TIYHLQPSGRFVIGGPQGDAGVTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAAR
WVAKSLVKAGLCRRVLVQVSYAIGVAEPLSISIFTYGTSKKTERDELLEVVNKNFDLRPG
VIVRDLDLKKPIYQKTACYGHFGRSEFPWEVPKKLVF
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Component 2 |
Name: | S-adenosylmethionine synthase isoform type-2 |
Synonyms: | AdoMet synthetase 2 | Ams2 | MAT 2 | MAT-II | METK2_RAT | Mat2a | Methionine adenosyltransferase 2 | Methionine adenosyltransferase II | S-Adenosylmethionine Synthase (AdoMet) | S-adenosylmethionine synthetase (MAT 1 and MAT 2) | S-adenosylmethionine synthetase gamma form | S-adenosylmethionine synthetase isoform type-2 |
Type: | PROTEIN |
Mol. Mass.: | 43713.68 |
Organism: | Rattus norvegicus |
Description: | ChEMBL_105118 |
Residue: | 395 |
Sequence: | MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQINDAVLDAHLQQDPDAKVACETVA
KTGMILLAGEITSRAAIDYQKVVREAIKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQG
VHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDS
KTQVTVQYMQDRGAVIPIRVHTIVISVQHDEEVCLDEMRDALKEKLIKAVVPAKYLDEDT
IYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARW
VAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKNNFDLRPGVI
VRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY
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BDBM50367328 |
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n/a |
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Name | BDBM50367328 |
Synonyms: | CHEMBL1791415 |
Type | Small organic molecule |
Emp. Form. | C15H26N7O13P3S |
Mol. Mass. | 637.392 |
SMILES | NC(CCSC(CP(O)(=O)OP(O)(=O)NP(O)(O)=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O |r| |
Structure |
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