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TargetBifunctional dihydrofolate reductase-thymidylate synthase
LigandBDBM50291767
Substrate/Competitorn/a
Meas. Tech.ChEMBL_55096 (CHEMBL875027)
Ki 1.95E3±n/a nM
Citation Booth, RGSelassie, CDHansch, CSanti, DV Quantitative structure-activity relationship of triazine-antifolate inhibition of Leishmania dihydrofolate reductase and cell growth. J Med Chem30:1218-24 (1987) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Bifunctional dihydrofolate reductase-thymidylate synthase
Name:Bifunctional dihydrofolate reductase-thymidylate synthase
Synonyms:DHFR-TS | DRTS_LEIMA | Thymidylate synthase (TS)
Type:Protein
Mol. Mass.:58691.04
Organism:Leishmania major
Description:P07382
Residue:520
Sequence:
MSRAAARFKIPMPETKADFAFPSLRAFSIVVALDMQHGIGDGESIPWRVPEDMTFFKNQT
TLLRNKKPPTEKKRNAVVMGRKTWESVPVKFRPLKGRLNIVLSSKATVEELLAPLPEGQR
AAAAQDVVVVNGGLAEALRLLARPLYCSSIETAYCVGGAQVYADAMLSPCIEKLQEVYLT
RIYATAPACTRFFPFPPENAATAWDLASSQGRRKSEAEGLEFEICKYVPRNHEERQYLEL
IDRIMKTGIVKEDRTGVGTISLFGAQMRFSLRDNRLPLLTTKRVFWRGVCEELLWFLRGE
TSAQLLADKDIHIWDGNGSREFLDSRGLTENKEMDLGPVYGFQWRHFGADYKGFEANYDG
EGVDQIKLIVETIKTNPNDRRLLVTAWNPCALQKMALPPCHLLAQFYVNTDTSELSCMLY
QRSCDMGLGVPFNIASYALLTILIAKATGLRPGELVHTLGDAHVYRNHVDALKAQLERVP
HAFPTLIFKEERQYLEDYELTDMEVIDYVPHPAIKMEMAV
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  Blast E-value cutoff:
BDBM50291767
n/a
NameBDBM50291767
Synonyms:1-(3-Ethyl-phenyl)-6,6-dimethyl-1,6-dihydro-[1,3,5]triazine-2,4-diamine | CHEMBL20874
TypeSmall organic molecule
Emp. Form.C13H19N5
Mol. Mass.245.3235
SMILESCCc1cccc(c1)N1C(N)=NC(N)=NC1(C)C |c:11,14|
Structure
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