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Reaction Details
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TargetDihydrofolate reductase
LigandBDBM50022831
Substrate/Competitorn/a
Meas. Tech.ChEMBL_54548 (CHEMBL664864)
Ki 57±n/a nM
Citation Taira, KBenkovic, SJ Evaluation of the importance of hydrophobic interactions in drug binding to dihydrofolate reductase. J Med Chem31:129-37 (1988) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Dihydrofolate reductase
Name:Dihydrofolate reductase
Synonyms:Dihydrofolate reductase (F31V) | dfrA17
Type:n/a
Mol. Mass.:17532.46
Organism:Escherichia coli
Description:n/a
Residue:157
Sequence:
MKISLISAVSESGVIGSGPDIPWSVKGEQLLFKALTYNQWLLVGRKTFDSMGVLPNRKYA
VVSKNGISSSNENVLVFPSIENALKELSKVTDHVYVSGGGQIYNSLIEKADIIHLSTVHV
EVEGDIKFPIMPENFNLVFEQFFMSNINYTYQIWKKG
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  Blast E-value cutoff:
BDBM50022831
n/a
NameBDBM50022831
Synonyms:6,7-Dimethyl-pteridine-2,4-diamine | CHEMBL29143
TypeSmall organic molecule
Emp. Form.C8H10N6
Mol. Mass.190.2052
SMILESCc1nc2nc(N)nc(N)c2nc1C
Structure
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