| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM50422885 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_54400 (CHEMBL667357) |
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| pH | 8.5±n/a |
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| Kd | 490±n/a nM |
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| Comments | extracted |
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| Citation |  Taira, K; Benkovic, SJ Evaluation of the importance of hydrophobic interactions in drug binding to dihydrofolate reductase. J Med Chem31:129-37 (1988) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | Dihydrofolate reductase (F31V) | dfrA17 |
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| Type: | n/a |
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| Mol. Mass.: | 17532.46 |
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| Organism: | Escherichia coli |
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| Description: | n/a |
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| Residue: | 157 |
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| Sequence: | MKISLISAVSESGVIGSGPDIPWSVKGEQLLFKALTYNQWLLVGRKTFDSMGVLPNRKYA
VVSKNGISSSNENVLVFPSIENALKELSKVTDHVYVSGGGQIYNSLIEKADIIHLSTVHV
EVEGDIKFPIMPENFNLVFEQFFMSNINYTYQIWKKG
|
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|
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| BDBM50422885 |
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| n/a |
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| Name | BDBM50422885 |
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| Synonyms: | CHEMBL2364573 | NADPH |
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| Type | Small organic molecule |
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| Emp. Form. | C21H28N7O17P3 |
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| Mol. Mass. | 743.405 |
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| SMILES | NC(=O)c1ccc[n+](c1)[C@H]1O[C@@H](COP([O-])(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)n2cnc3c(N)ncnc23)[C@H](O)[C@@H]1O |r| |
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| Structure | 
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