| Reaction Details |
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 | Report a problem with these data |
| Target | D(1A) dopamine receptor |
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| Ligand | BDBM50022053 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_58650 |
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| Ki | 174±n/a nM |
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| Citation |  Charifson, PS; Wyrick, SD; Hoffman, AJ; Simmons, RM; Bowen, JP; McDougald, DL; Mailman, RB Synthesis and pharmacological characterization of 1-phenyl-, 4-phenyl-, and 1-benzyl-1,2,3,4-tetrahydroisoquinolines as dopamine receptor ligands. J Med Chem31:1941-6 (1988) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| D(1A) dopamine receptor |
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| Name: | D(1A) dopamine receptor |
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| Synonyms: | DOPAMINE D1 | DRD1_RAT | Dopamine D1 high | Dopamine D1 low | Dopamine receptor | Dopamine receptor D1 | Dopamine1-like | Drd1 | Drd1a |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 49429.75 |
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| Organism: | RAT |
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| Description: | P18901 |
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| Residue: | 446 |
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| Sequence: | MAPNTSTMDEAGLPAERDFSFRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNF
FVISLAVSDLLVAVLVMPWKAVAEIAGFWPLGPFCNIWVAFDIMCSTASILNLCVISVDR
YWAISSPFQYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTWPLDGNFTSLED
TEDDNCDTRLSRTYAISSSLISFYIPVAIMIVTYTSIYRIAQKQIRRISALERAAVHAKN
CQTTAGNGNPVECAQSESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFISNCMVPFCGS
EETQPFCIDSITFDVFVWFGWANSSLNPIIYAFNADFQKAFSTLLGCYRLCPTTNNAIET
VSINNNGAVVFSSHHEPRGSISKDCNLVYLIPHAVGSSEDLKKEEAGGIAKPLEKLSPAL
SVILDYDTDVSLEKIQPVTHSGQHST
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| BDBM50022053 |
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| n/a |
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| Name | BDBM50022053 |
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| Synonyms: | 1-Benzyl-6-chloro-2-methyl-1,2,3,4-tetrahydro-isoquinolin-7-ol | 7-Chloro-2-methyl-4-phenyl-1,2,3,4-tetrahydro-isoquinolin-6-ol | CHEMBL299056 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H16ClNO |
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| Mol. Mass. | 273.757 |
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| SMILES | CN1CC(c2ccccc2)c2cc(O)c(Cl)cc2C1 |
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| Structure | 
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