| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM50367055 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_54449 |
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| IC50 | 2±n/a nM |
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| Citation |  Rosowsky, A; Bader, H; Forsch, RA; Moran, RG; Freisheim, JH Methotrexate analogues. 31. Meta and ortho isomers of aminopterin, compounds with a double bond in the side chain, and a novel analogue modified at the alpha-carbon: chemical and in vitro biological studies. J Med Chem31:763-8 (1988) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | DYR_MOUSE | Dhfr |
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| Type: | Enzyme |
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| Mol. Mass.: | 21608.82 |
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| Organism: | Mus musculus (Mouse) |
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| Description: | n/a |
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| Residue: | 187 |
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| Sequence: | MVRPLNCIVAVSQNMGIGKNGDLPWPPLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFS
IPEKNRPLKDRINIVLSRELKEPPRGAHFLAKSLDDALRLIEQPELASKVDMVWIVGGSS
VYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLGKYKLLPEYPGVLSEVQEEKGIKYKF
EVYEKKD
|
|
|
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| BDBM50367055 |
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| n/a |
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| Name | BDBM50367055 |
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| Synonyms: | 4-Aminofolic acid | 4-Aminopteroic acid | AMINOPTERIN | Aminopteroylglutamic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C19H20N8O5 |
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| Mol. Mass. | 440.4127 |
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| SMILES | Nc1nc(N)c2nc(CNc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)cnc2n1 |r| |
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| Structure | 
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