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TargetKappa-type opioid receptor
LigandBDBM50018762
Substrate/Competitorn/a
Meas. Tech.ChEBML_147220
Ki 4.2±n/a nM
Citation Clark, CR; Halfpenny, PR; Hill, RG; Horwell, DC; Hughes, J; Jarvis, TC; Rees, DC; Schofield, D Highly selective kappa opioid analgesics. Synthesis and structure-activity relationships of novel N-[(2-aminocyclohexyl)aryl]acetamide and N-[(2-aminocyclohexyl)aryloxy]acetamide derivatives. J Med Chem31:831-6 (1988) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Kappa-type opioid receptor
Name:Kappa-type opioid receptor
Synonyms:Kappa Opioid Receptor | OPIATE Kappa | OPRK1 | OPRK_CAVPO | Opiate Kappa 1 | mu/kappa opioid receptor
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:42744.99
Organism:Cavia porcellus (domestic guinea pig)
Description:P41144
Residue:380
Sequence:
MGRRRQGPAQPASELPARNACLLPNGSAWLPGWAEPDGNGSAGPQDEQLEPAHISPAIPV
IITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYL
MNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINI
CIWLLSSSVGISAIILGGTKVREDVDIIECSLQFPDDDYSWWDLFMKICVFVFAFVIPVL
IIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFIICWTPIHIFILVEALG
STSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPIKMRMERQSTSRV
RNTVQDPAYMRNVDGVNKPV
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BDBM50018762
n/a
NameBDBM50018762
Synonyms:2-Benzofuran-4-yl-N-methyl-N-(2-pyrrolidin-1-yl-cyclohexyl)-acetamide; hydrobromide, Hydrate | 2-Benzofuran-4-yl-N-methyl-N-(2-pyrrolidin-1-yl-cyclohexyl)-acetamide; hydrochloride | 2-Benzofuran-4-yl-N-methyl-N-(2-pyrrolidin-1-yl-cyclohexyl)-acetamide; hydrochloride, Hydrate | CHEMBL558608
TypeSmall organic molecule
Emp. Form.C21H28N2O2
Mol. Mass.340.4592
SMILESCN([C@@H]1CCCC[C@H]1N1CCCC1)C(=O)Cc1cccc2occc12
Structure
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