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TargetDihydrofolate reductase
LigandBDBM50023718
Substrate/Competitorn/a
Meas. Tech.ChEBML_54443
IC50 28±n/a nM
Citation Rosowsky, ABader, HCucchi, CAMoran, RGKohler, WFreisheim, JH Methotrexate analogues. 33. N delta-acyl-N alpha-(4-amino-4-deoxypteroyl)-L-ornithine derivatives: synthesis and in vitro antitumor activity. J Med Chem31:1332-7 (1988) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Dihydrofolate reductase
Name:Dihydrofolate reductase
Synonyms:DYR_MOUSE | Dhfr
Type:Enzyme
Mol. Mass.:21608.82
Organism:Mus musculus (Mouse)
Description:n/a
Residue:187
Sequence:
MVRPLNCIVAVSQNMGIGKNGDLPWPPLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFS
IPEKNRPLKDRINIVLSRELKEPPRGAHFLAKSLDDALRLIEQPELASKVDMVWIVGGSS
VYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLGKYKLLPEYPGVLSEVQEEKGIKYKF
EVYEKKD
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  Blast E-value cutoff:
BDBM50023718
n/a
NameBDBM50023718
Synonyms:5-Acetylamino-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-amino]-benzoylamino}-pentanoic acid | CHEMBL423297
TypeSmall organic molecule
Emp. Form.C21H25N9O4
Mol. Mass.467.4811
SMILESCC(=O)NCCCC(NC(=O)c1ccc(NCc2cnc3nc(N)nc(N)c3n2)cc1)C(O)=O
Structure
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