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TargetDihydrofolate reductase
LigandBDBM50023714
Substrate/Competitorn/a
Meas. Tech.ChEBML_54443
IC50 56±n/a nM
Citation Rosowsky, ABader, HCucchi, CAMoran, RGKohler, WFreisheim, JH Methotrexate analogues. 33. N delta-acyl-N alpha-(4-amino-4-deoxypteroyl)-L-ornithine derivatives: synthesis and in vitro antitumor activity. J Med Chem31:1332-7 (1988) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Dihydrofolate reductase
Name:Dihydrofolate reductase
Synonyms:DYR_MOUSE | Dhfr
Type:Enzyme
Mol. Mass.:21608.82
Organism:Mus musculus (Mouse)
Description:n/a
Residue:187
Sequence:
MVRPLNCIVAVSQNMGIGKNGDLPWPPLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFS
IPEKNRPLKDRINIVLSRELKEPPRGAHFLAKSLDDALRLIEQPELASKVDMVWIVGGSS
VYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLGKYKLLPEYPGVLSEVQEEKGIKYKF
EVYEKKD
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BDBM50023714
n/a
NameBDBM50023714
Synonyms:2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-formyl-amino]-benzoylamino}-5-(3,4-dichloro-benzoylamino)-pentanoic acid | CHEMBL405237
TypeSmall organic molecule
Emp. Form.C27H25Cl2N9O5
Mol. Mass.626.451
SMILESNc1nc(N)c2nc(CN(C=O)c3ccc(cc3)C(=O)NC(CCCNC(=O)c3ccc(Cl)c(Cl)c3)C(O)=O)cnc2n1
Structure
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