| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM50020104 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_54452 |
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| IC50 | 67±n/a nM |
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| Citation |  Rosowsky, A; Bader, H; Kohler, W; Freisheim, JH; Moran, RG Methotrexate analogues. 34. Replacement of the glutamate moiety in methotrexate and aminopterin by long-chain 2-aminoalkanedioic acids. J Med Chem31:1338-44 (1988) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | DYR_MOUSE | Dhfr |
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| Type: | Enzyme |
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| Mol. Mass.: | 21608.82 |
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| Organism: | Mus musculus (Mouse) |
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| Description: | n/a |
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| Residue: | 187 |
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| Sequence: | MVRPLNCIVAVSQNMGIGKNGDLPWPPLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFS
IPEKNRPLKDRINIVLSRELKEPPRGAHFLAKSLDDALRLIEQPELASKVDMVWIVGGSS
VYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLGKYKLLPEYPGVLSEVQEEKGIKYKF
EVYEKKD
|
|
|
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| BDBM50020104 |
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| n/a |
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| Name | BDBM50020104 |
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| Synonyms: | 2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-amino]-benzoylamino}-tridecanedioic acid | CHEMBL275229 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H36N8O5 |
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| Mol. Mass. | 552.6253 |
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| SMILES | Nc1nc(N)c2nc(CNc3ccc(cc3)C(=O)NC(CCCCCCCCCCC(O)=O)C(O)=O)cnc2n1 |
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| Structure | 
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