Reaction Details |
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Target | Folylpolyglutamate synthase, mitochondrial |
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Ligand | BDBM50020102 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_68680 |
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Ki | 20000±n/a nM |
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Citation | Rosowsky, A; Bader, H; Kohler, W; Freisheim, JH; Moran, RG Methotrexate analogues. 34. Replacement of the glutamate moiety in methotrexate and aminopterin by long-chain 2-aminoalkanedioic acids. J Med Chem31:1338-44 (1988) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Folylpolyglutamate synthase, mitochondrial |
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Name: | Folylpolyglutamate synthase, mitochondrial |
Synonyms: | FOLC_MOUSE | Folylpoly-gamma-glutamate synthetase | Folylpolyglutamate synthase, mitochondrial | Fpgs | Tetrahydrofolate synthase | Tetrahydrofolylpolyglutamate synthase |
Type: | PROTEIN |
Mol. Mass.: | 64969.76 |
Organism: | Mus musculus |
Description: | ChEMBL_68680 |
Residue: | 587 |
Sequence: | MSWARSRLCSTLSLAAVSARGATTEGAARRGMSAWPAPQEPGMEYQDAVRTLNTLQTNAS
YLEQVKRQRSDPQAQLEAMEMYLARSGLQVEDLNRLNIIHVTGTKGKGSTCAFTERILRN
YGLKTGFFSSPHMVQVRERIRINGKPISPELFTKHFWCLYNQLEEFKDDSHVSMPSYFRF
LTLMAFHVFLQEKVDLAVVEVGIGGAFDCTNIIRKPVVCGVSSLGIDHTSLLGDTVEKIA
WQKGGIFKPGVPAFTVVQPEGPLAVLRDRAQQIGCPLYLCPPLEALEEVGLPLSLGLEGA
HQRSNAALALQLAHCWLERQDHQDIQELKVSRPSIRWQLPLAPVFRPTPHMRRGLRDTVW
PGRTQILQRGPLTWYLDGAHTTSSVQACVHWYRQSLERSKRTDGGSEVHILLFNSTGDRD
SAALLKLLQPCQFDYAVFCPNVTEVSSIGNADQQNFTVTLDQVLLRCLQHQQHWNGLAEK
QASSNLWSSCGPDPAGPGSLLLAPHPPQPTRTSSLVFSCISHALLWISQGRDPIFQPQSL
PRNLLNHPTANSGASILREAAAIHVLVTGSLHLVGGVLKLLDPSMSQ
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BDBM50020102 |
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n/a |
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Name | BDBM50020102 |
Synonyms: | 5-Amino-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-pentanoic acid | CHEMBL28049 |
Type | Small organic molecule |
Emp. Form. | C20H25N9O3 |
Mol. Mass. | 439.471 |
SMILES | CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(cc1)C(=O)N[C@@H](CCCN)C(O)=O |
Structure |
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